INT20377

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Context Info
Confidence 0.65
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.82
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il3) extracellular region (Il3)
Anatomy Link Frequency
Leukocyte 1
dendritic cells 1
mast cell 1
Il3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 58 100.00 Very High Very High Very High
cytokine 229 99.68 Very High Very High Very High
Inflammatory response 17 99.04 Very High Very High Very High
Inflammation 149 92.72 High High
tolerance 4 91.44 High High
Neuropathic pain 18 50.00 Quite Low
palliative 3 50.00 Quite Low
Central nervous system 1 40.88 Quite Low
Inflammatory stimuli 15 38.08 Quite Low
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 185 99.04 Very High Very High Very High
Shock 1 70.08 Quite High
Neurodegenerative Disease 1 60.32 Quite High
Adhesions 10 59.04 Quite High
Diabetes Mellitus 52 55.28 Quite High
Lymphatic System Cancer 4 53.68 Quite High
Apoptosis 85 50.00 Quite Low
Mucositis 74 50.00 Quite Low
Neuropathic Pain 19 50.00 Quite Low
General Immunology 7 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GM-CSF/IL-3/IL-5 receptors are a family of heterodimeric transmembrane proteins expressed by dendritic cells and other myeloid lineage cells, which also transmit activation signals through these complex pathways.
Gene_expression (expressed) of IL-3 in dendritic cells
1) Confidence 0.65 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.18 Pain Relevance 0.09
The level of IL-3 produced by CD8+ clones was approximately 10% of that produced by Th1 and Th2 clones.
Gene_expression (produced) of IL-3
2) Confidence 0.35 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.17
The level of IL-3 produced by CD8+ clones was approximately 10% of that produced by Th1 and Th2 clones.
Gene_expression (produced) of IL-3
3) Confidence 0.31 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.17
, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12p70, IL-17, GM-CSF, KC, and RANTES induction discriminate between the effects of BCG relative to the inflammatory responses obtained with LPS and TNF-?
Gene_expression (effects) of IL-3 associated with chemokine and inflammatory response
4) Confidence 0.17 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.38 Pain Relevance 0.73
IL-3 and GM-CSF also induce the differentiation of other myeloid cells such as the mast cell, but IL-3, GM-CSF and IL-5 synergize toward the differentiation of eosinophils.
Gene_expression (synergize) of IL-3 in mast cell
5) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0 Pain Relevance 0.13
3) Leukocyte developmental: regulating immature white cell growth and differentiation; IL-3 and IL-7 represent this category.
Gene_expression (represent) of IL-3 in Leukocyte
6) Confidence 0.09 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.06 Pain Relevance 0
The earliest cytokines induced by BCG included: IL-12 (p70 and p40), IL-2, IL-3, IL-4, MIP-1?
Gene_expression (included) of IL-3 associated with cytokine
7) Confidence 0.07 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.15 Pain Relevance 0.48
Runx1a was shown to transactivate the human interleukin-3 promoter, albeit with less efficiency than Runx1b (long isoform) (5).
Gene_expression (transactivate) of interleukin-3 promoter
8) Confidence 0.04 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.06 Pain Relevance 0

General Comments

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