INT20379

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Context Info
Confidence 0.73
First Reported 1990
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 85
Total Number 86
Disease Relevance 51.22
Pain Relevance 20.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 11
Th2 cells 8
lymphocytes 4
spleen 4
PSP 3
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1662 100.00 Very High Very High Very High
Inflammation 1208 100.00 Very High Very High Very High
Analgesic 21 100.00 Very High Very High Very High
Endogenous opioid 2 100.00 Very High Very High Very High
narcan 6 99.92 Very High Very High Very High
fluoxetine 10 99.84 Very High Very High Very High
Inflammatory mediators 22 99.68 Very High Very High Very High
antagonist 49 99.56 Very High Very High Very High
Arthritis 540 99.36 Very High Very High Very High
Sciatic nerve 1 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1276 100.00 Very High Very High Very High
Targeted Disruption 175 99.76 Very High Very High Very High
Asthma 535 99.68 Very High Very High Very High
Cancer 191 99.64 Very High Very High Very High
Sprains And Strains 416 99.52 Very High Very High Very High
Necrosis 68 99.40 Very High Very High Very High
Pneumonia 239 99.38 Very High Very High Very High
Arthritis 562 99.36 Very High Very High Very High
Hypersensitivity 294 99.32 Very High Very High Very High
Rheumatoid Arthritis 431 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression was maintained on CD3+ T cells, CD19+ B cells (Figure 1D), and macrophages (unpublished data) in smooth muscle cell–specific IL-4R?
Localization (specific) of IL-4 in macrophages
1) Confidence 0.73 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.42 Pain Relevance 0
Our results demonstrate that IL-4, -10, and -13 display analgesic activity that is probably not due to endogenous opioid release.
Localization (release) of IL-4 associated with analgesic and endogenous opioid
2) Confidence 0.71 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490580 Disease Relevance 0.31 Pain Relevance 0.83
IL-4, -10, or -13 significantly inhibited the release of both tumor necrosis factor (TNF)-alpha (60, 53, and 100%, respectively) and IL-1beta (80, 100, and 100%, respectively) by mice peritoneal macrophages obtained after local (i.p.) injection of zymosan.
Localization (release) of IL-4 in peritoneal macrophages associated with necrosis and cancer
3) Confidence 0.71 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490580 Disease Relevance 0.37 Pain Relevance 0.79
Fluoxetine administration for 1 and 2 weeks, but not 4 weeks, stimulates the proliferative activity of splenocytes, whereas a 4-week administration of fluoxetine suppresses the secretion of IL-4.
Localization (secretion) of IL-4 associated with fluoxetine
4) Confidence 0.69 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084221 Disease Relevance 0.18 Pain Relevance 0.85
Citalopram administered for 1, 2 and 4 weeks stimulates the proliferative activity of splenocytes and suppresses their ability to secrete the anti-inflammatory cytokine IL-4.
Localization (secrete) of cytokine IL-4 associated with inflammation and cytokine
5) Confidence 0.61 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084221 Disease Relevance 0.17 Pain Relevance 0.82
Beta-endorphin stimulates Ia expression on mouse B cells by inducing interleukin-4 secretion by CD4+ T cells.
Localization (secretion) of interleukin-4 in T cells associated with narcan
6) Confidence 0.60 Published 1993 Journal Cell. Immunol. Section Title Doc Link 8099850 Disease Relevance 0 Pain Relevance 0.15
/IL-4 were decreased significantly (P < .01) compared with group B (LPS treatment only).
Localization (decreased) of IL-4
7) Confidence 0.59 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.37 Pain Relevance 0
Parallel bioassays showed that secreted IL-2/IL-4 activity levels and mRNA levels correlated well for all clones.
Localization (secreted) of IL-4
8) Confidence 0.58 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 8381052 Disease Relevance 0.23 Pain Relevance 0.09
Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secretion.
Localization (secretion) of interleukin 4
9) Confidence 0.56 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.63 Pain Relevance 0.15
Splenocytes were obtained and cultured in vitro with H. pylori sonicate to evaluate induction of interferon gamma (IFN-gamma) and interleukin 4 (IL-4) secretion.
Localization (secretion) of IL-4
10) Confidence 0.56 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.63 Pain Relevance 0.15
IL-4 is secreted by Th2 cells, which are the major modulating cells of humoral immunity.
Localization (secreted) of IL-4 in Th2 cells
11) Confidence 0.55 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.37 Pain Relevance 0.30
The function of CIITA in Th differentiation was first demonstrated by the observation of increased generation of IL-4 secreting CD4+ T cells in CIITA-/-I-E-transgenic mice (12).
Localization (secreting) of IL-4 in T cells associated with targeted disruption
12) Confidence 0.52 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.00 Pain Relevance 0.03
In this model, the inflammation is characterized by increased IL-4 and IL-5 secretion and the inflammation can be ameliorated by the administration of anti-IL-4 antibodies (15).
Localization (secretion) of IL-4 associated with inflammation
13) Confidence 0.52 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.16 Pain Relevance 0.13
And, CD4+ T cells from the mesenteric lymph node of CIITA-transgenic mice treated with oxazolone exhibited a high level of IL-4 secretion.
Localization (secretion) of IL-4 in T cells associated with targeted disruption
14) Confidence 0.45 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721999 Disease Relevance 0.88 Pain Relevance 0.04
However, the data shown by Otten et al. and our group were in sharp contrast with the prediction, in that the two independent CIITA-Tg mice (ectopic expression of CIITA in all types of cells in the body and restricted expression of the molecule in mature T cells, respectively) rendered the transgenic CD4+ T cells to differentiate preferentially into IL-4 secreting Th2-type cells in vitro (13, 14).
Localization (secreting) of IL-4 in mature T cells associated with targeted disruption
15) Confidence 0.45 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.79 Pain Relevance 0
secretion as well as impaired Th1 polarization in vitro, while IL-4 secretion was enhanced under the Th2 condition (13).
Localization (secretion) of IL-4
16) Confidence 0.45 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.43 Pain Relevance 0.06
The PG-specific and arthritogenic T cell hybridoma (5/4E8) expressed TCR-alpha beta + (V beta 4), CD4+, and CD8- phenotypes and belonged to the Th1 subset, as the cells secreted IL-2 and IFN-gamma, but not IL-4 upon PG stimulation, and the response was MHC class II (I-Ad)-restricted.
Neg (not) Localization (secreted) of IL-4 in T cell
17) Confidence 0.42 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7544381 Disease Relevance 0.59 Pain Relevance 0.22
(Fig. 6, panels A and B), but significantly reduced both IL-10 and IL-4 release (Fig. 6, panels C and D).
Localization (release) of IL-4
18) Confidence 0.42 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.16 Pain Relevance 0.04
asthma, including the secretion of cytokines such as IL-4, IL-5, and IL-13,
Localization (secretion) of IL-4 associated with asthma and cytokine
19) Confidence 0.39 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.49 Pain Relevance 0.10
IL-4 is the hallmark cytokine of the Th2 phenotype, but IL-10 is secreted by Th2 cells and a number of the recently identified Treg populations that play a crucial role in limiting inflammation [25,26].
Localization (secreted) of IL-4 in Th2 cells associated with inflammation and cytokine
20) Confidence 0.39 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.15 Pain Relevance 0.14

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