INT2038

Context Info Confidence 0.79 First Reported 1977 Last Reported 2011 Negated 2 Speculated 2 Reported most in Body Documents 104 Total Number 106 Disease Relevance 40.12 Pain Relevance 13.27

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1) cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)

Anatomy Link Frequency reticulum 6 brain 2 plasma 1 cleavage 1 pore 1 Esr1 (Mus musculus)

Pain Link Frequency Relevance Heat Oxycodone 2 100.00 Hippocampus 148 99.92 agonist 361 99.84 aspirin 12 99.78 Glutamate 358 99.52 Analgesic 2 99.48 ischemia 583 99.32 Arthritis 587 99.26 opioid receptor 10 99.20 transdermal 4 99.20

Disease Link Frequency Relevance Heat Hypersensitivity 193 100.00 Anaerobic Bacterial Infections 36 100.00 Hypoxia 1482 99.92 Weight Loss 7 99.60 Stress 348 99.56 Diabetes Mellitus 304 99.34 Cv General 4 Under Development 367 99.32 Cancer 439 99.28 Congenital Anomalies 23 99.28 Experimental Arthritis 348 99.26

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, immunohistochemical localization of the truncated ER?

Localization (localization) of ER

1) Confidence 0.79 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.74 Pain Relevance 0

The question was raised as to why raloxifene exerted antitumor effects on mammary tumors that expressed the cytoplasmically located ER?

Localization (located) of ER associated with cancer

2) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.40 Pain Relevance 0

CRP and ESR also improved significantly after 3 months (p<0.001, for both comparisons) (Table 2).

Localization (improved) of ESR

3) Confidence 0.73 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580004 Disease Relevance 0.41 Pain Relevance 0.22

Cloning of ER?

Localization (Cloning) of ER

4) Confidence 0.71 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.31 Pain Relevance 0.37

agonist displaying a more than 484-fold selectivity over ER?

Localization (selectivity) of ER associated with agonist

5) Confidence 0.71 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.42 Pain Relevance 0.46

CH4893237 reduced the amount of ER at the protein level and impaired the nuclear accumulation of ER, indicating an orally active pure anti-estrogen.

Localization (accumulation) of ER

6) Confidence 0.70 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.38 Pain Relevance 0.29

CONCLUSIONS: Our study does not support a major contribution of ESR1 and PGR to the pathogenesis of migraine.

Localization (contribution) of ESR1

7) Confidence 0.66 Published 2009 Journal Eur. J. Neurol. Section Body Doc Link 19175383 Disease Relevance 0.07 Pain Relevance 0

The rapid release of 3H-estradiol from estrogen-receptor complexes at 0 degrees C is implemented by combinations of the local anesthetic tetracaine and certain sulfated polysaccharides.

Localization (release) of estrogen-receptor associated with local anesthetic

8) Confidence 0.65 Published 1983-1984 Journal J. Recept. Res. Section Abstract Doc Link 6207294 Disease Relevance 0 Pain Relevance 0.10

Value of measurement of the articular index and sigma ESR].

Localization (measurement) of ESR in articular

9) Confidence 0.65 Published 1977 Journal Nouv Presse Med Section Title Doc Link 319424 Disease Relevance 0.10 Pain Relevance 0.31

Raloxifene acts on both nuclear ER?

Localization (nuclear) of ER

10) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.39 Pain Relevance 0

is apparently different from the present ER?

Localization (different) of ER

11) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.64 Pain Relevance 0

ERA-63 inhibits the tetanus toxoid (TT)-specific DTH response in WT and ER?

Localization (response) of ERA-63 associated with hypersensitivity and anaerobic bacterial infections

12) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.66 Pain Relevance 0.22

Pharmacologic characterization of the selective ER?

Localization (characterization) of ER

13) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.68 Pain Relevance 0.50

Finally, EE and a selective ER?

Localization (selective) of ER

14) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.32 Pain Relevance 0.64

based on in vitro ER?

Localization (based) of ER

15) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.42 Pain Relevance 0.46

ERA-63 inhibits the tetanus toxoid (TT)-specific DTH response in WT and ER?

Localization (response) of ER associated with hypersensitivity and anaerobic bacterial infections

16) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.65 Pain Relevance 0.21

Immunohistochemistry revealed a clear nuclear localization of ER?

Spec (clear) Localization (localization) of ER

17) Confidence 0.55 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0

Oestrogen treatment is clearly protective in collagen induced arthritis (CIA) and pharmacologic blocking of both nuclear ER?

Localization (nuclear) of ER associated with experimental arthritis and arthritis

18) Confidence 0.53 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.43 Pain Relevance 0.18

Response to therapy is indicated by resolution of symptoms, normalization of ESR, and reversal of abnormalities on radionuclide scans.

Localization (normalization) of ESR associated with congenital anomalies

19) Confidence 0.52 Published 1991 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 1901156 Disease Relevance 0.50 Pain Relevance 0.05

The initial objective of the study was to use immunohistochemistry and Western blotting to localise ER?

Localization (localise) of ER

20) Confidence 0.51 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.