INT2038

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Context Info
Confidence 0.79
First Reported 1977
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 104
Total Number 106
Disease Relevance 40.12
Pain Relevance 13.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
reticulum 6
brain 2
plasma 1
cleavage 1
pore 1
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Oxycodone 2 100.00 Very High Very High Very High
Hippocampus 148 99.92 Very High Very High Very High
agonist 361 99.84 Very High Very High Very High
aspirin 12 99.78 Very High Very High Very High
Glutamate 358 99.52 Very High Very High Very High
Analgesic 2 99.48 Very High Very High Very High
ischemia 583 99.32 Very High Very High Very High
Arthritis 587 99.26 Very High Very High Very High
opioid receptor 10 99.20 Very High Very High Very High
transdermal 4 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 193 100.00 Very High Very High Very High
Anaerobic Bacterial Infections 36 100.00 Very High Very High Very High
Hypoxia 1482 99.92 Very High Very High Very High
Weight Loss 7 99.60 Very High Very High Very High
Stress 348 99.56 Very High Very High Very High
Diabetes Mellitus 304 99.34 Very High Very High Very High
Cv General 4 Under Development 367 99.32 Very High Very High Very High
Cancer 439 99.28 Very High Very High Very High
Congenital Anomalies 23 99.28 Very High Very High Very High
Experimental Arthritis 348 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, immunohistochemical localization of the truncated ER?
Localization (localization) of ER
1) Confidence 0.79 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.74 Pain Relevance 0
The question was raised as to why raloxifene exerted antitumor effects on mammary tumors that expressed the cytoplasmically located ER?
Localization (located) of ER associated with cancer
2) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.40 Pain Relevance 0
CRP and ESR also improved significantly after 3 months (p<0.001, for both comparisons) (Table 2).
Localization (improved) of ESR
3) Confidence 0.73 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580004 Disease Relevance 0.41 Pain Relevance 0.22
Cloning of ER?
Localization (Cloning) of ER
4) Confidence 0.71 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.31 Pain Relevance 0.37
agonist displaying a more than 484-fold selectivity over ER?
Localization (selectivity) of ER associated with agonist
5) Confidence 0.71 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.42 Pain Relevance 0.46
CH4893237 reduced the amount of ER at the protein level and impaired the nuclear accumulation of ER, indicating an orally active pure anti-estrogen.
Localization (accumulation) of ER
6) Confidence 0.70 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.38 Pain Relevance 0.29
CONCLUSIONS: Our study does not support a major contribution of ESR1 and PGR to the pathogenesis of migraine.


Localization (contribution) of ESR1
7) Confidence 0.66 Published 2009 Journal Eur. J. Neurol. Section Body Doc Link 19175383 Disease Relevance 0.07 Pain Relevance 0
The rapid release of 3H-estradiol from estrogen-receptor complexes at 0 degrees C is implemented by combinations of the local anesthetic tetracaine and certain sulfated polysaccharides.
Localization (release) of estrogen-receptor associated with local anesthetic
8) Confidence 0.65 Published 1983-1984 Journal J. Recept. Res. Section Abstract Doc Link 6207294 Disease Relevance 0 Pain Relevance 0.10
Value of measurement of the articular index and sigma ESR].
Localization (measurement) of ESR in articular
9) Confidence 0.65 Published 1977 Journal Nouv Presse Med Section Title Doc Link 319424 Disease Relevance 0.10 Pain Relevance 0.31
Raloxifene acts on both nuclear ER?
Localization (nuclear) of ER
10) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.39 Pain Relevance 0
is apparently different from the present ER?
Localization (different) of ER
11) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.64 Pain Relevance 0
ERA-63 inhibits the tetanus toxoid (TT)-specific DTH response in WT and ER?
Localization (response) of ERA-63 associated with hypersensitivity and anaerobic bacterial infections
12) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.66 Pain Relevance 0.22
Pharmacologic characterization of the selective ER?
Localization (characterization) of ER
13) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.68 Pain Relevance 0.50
Finally, EE and a selective ER?
Localization (selective) of ER
14) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.32 Pain Relevance 0.64
based on in vitro ER?
Localization (based) of ER
15) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.42 Pain Relevance 0.46
ERA-63 inhibits the tetanus toxoid (TT)-specific DTH response in WT and ER?
Localization (response) of ER associated with hypersensitivity and anaerobic bacterial infections
16) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.65 Pain Relevance 0.21
Immunohistochemistry revealed a clear nuclear localization of ER?
Spec (clear) Localization (localization) of ER
17) Confidence 0.55 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Oestrogen treatment is clearly protective in collagen induced arthritis (CIA) and pharmacologic blocking of both nuclear ER?
Localization (nuclear) of ER associated with experimental arthritis and arthritis
18) Confidence 0.53 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.43 Pain Relevance 0.18
Response to therapy is indicated by resolution of symptoms, normalization of ESR, and reversal of abnormalities on radionuclide scans.
Localization (normalization) of ESR associated with congenital anomalies
19) Confidence 0.52 Published 1991 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 1901156 Disease Relevance 0.50 Pain Relevance 0.05
The initial objective of the study was to use immunohistochemistry and Western blotting to localise ER?
Localization (localise) of ER
20) Confidence 0.51 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.09 Pain Relevance 0

General Comments

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