INT20380

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2011
Negated 14
Speculated 2
Reported most in Body
Documents 172
Total Number 175
Disease Relevance 104.75
Pain Relevance 34.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
T cells 18
lung 11
eosinophils 11
Th2 cells 4
fibroblasts 3
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3893 100.00 Very High Very High Very High
cytokine 3106 100.00 Very High Very High Very High
Inflammatory response 260 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
Action potential 3 100.00 Very High Very High Very High
tetrodotoxin 2 100.00 Very High Very High Very High
Morphine 21 99.72 Very High Very High Very High
substance P 17 99.56 Very High Very High Very High
agonist 210 99.36 Very High Very High Very High
chemokine 694 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4119 100.00 Very High Very High Very High
Targeted Disruption 347 100.00 Very High Very High Very High
Cancer 340 100.00 Very High Very High Very High
Necrosis 150 100.00 Very High Very High Very High
Sprains And Strains 927 99.92 Very High Very High Very High
Eosinophilia 351 99.90 Very High Very High Very High
Hypersensitivity 1534 99.84 Very High Very High Very High
Asthma 3342 99.80 Very High Very High Very High
Hypereosinophilic Syndrome 223 99.54 Very High Very High Very High
Eczema 230 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eosinophilia, a hallmark of both helminth infections and atopic diseases, is maintained through upregulation of eosinophilopoiesis by means of increased production and effectiveness of Interleukin-5 (IL-5), a major Th2 cytokine.
Gene_expression (production) of Interleukin-5 associated with worm infection, disease, eosinophilia and cytokine
1) Confidence 0.78 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691935 Disease Relevance 0.83 Pain Relevance 0.23
Eosinophilia, a hallmark of both helminth infections and atopic diseases, is maintained through upregulation of eosinophilopoiesis by means of increased production and effectiveness of Interleukin-5 (IL-5), a major Th2 cytokine.
Gene_expression (production) of IL-5 associated with worm infection, disease, eosinophilia and cytokine
2) Confidence 0.78 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691935 Disease Relevance 0.83 Pain Relevance 0.23
The GM-CSF/IL-3/IL-5 receptors are a family of heterodimeric transmembrane proteins expressed by dendritic cells and other myeloid lineage cells, which also transmit activation signals through these complex pathways.
Gene_expression (expressed) of IL-5 in dendritic cells
3) Confidence 0.75 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.18 Pain Relevance 0.09
We observed that although the accumulation of lymphocytes in the airways of PPNK-deficient mice was similar to that induced in control mice, IL-5 production and eosinophil infiltration were reduced.
Gene_expression (production) of IL-5 in eosinophil
4) Confidence 0.55 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10808051 Disease Relevance 0.43 Pain Relevance 0.04
agonists have been shown to reduce IL4, IL5, and IL13 production from Tcells of mice with induced lung inflammation [38,49].
Gene_expression (production) of IL5 in lung associated with inflammation, agonist and pneumonia
5) Confidence 0.54 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.46 Pain Relevance 0.36
The time course of ovalbumin-induced production of the bronchoalveolar lavage T-helper 2 cytokines (interleukin-5 and interleukin-4) was also studied.
Gene_expression (production) of interleukin-5 associated with cytokine
6) Confidence 0.50 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.58 Pain Relevance 0.30
Similarly, a significant inhibition of allergen-induced interleukin-5 production on day 1 and eosinophilia on day 2 was observed at a dose of 0.3 mg/kg of budesonide in females only.
Gene_expression (production) of interleukin-5 associated with eosinophilia
7) Confidence 0.50 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.87 Pain Relevance 0.39
8.2 TCR transgenic mice stimulated with MBP Ac 1-11 peptide in the presence of testosterone resulted in increased production of IL-10 and IL-5 and decreased production of IFN-?
Gene_expression (production) of IL-5 associated with targeted disruption
8) Confidence 0.48 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.64 Pain Relevance 0.30
In contrast to the deleterious Th1 responses described above, Th2 responses, which include the production of cytokines such as IL-4, IL-5 and IL-10, are thought to be beneficial in MS.
Gene_expression (production) of IL-5 associated with multiple sclerosis and cytokine
9) Confidence 0.48 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.60 Pain Relevance 0.67
Treatment with highest dose of retinoic acid abolished airway hyperresponsiveness and downregulated expression of IL-5
Gene_expression (expression) of IL-5
10) Confidence 0.48 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0 Pain Relevance 0
In concordance with results of airway eosinophilia, levels of IL-5 expression in parenchyma cells and lung function were also abolished by treatment with highest doses of retinoic acid.
Gene_expression (expression) of IL-5 in parenchyma associated with eosinophilia
11) Confidence 0.48 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.38 Pain Relevance 0.03
However, approximately 10-fold more interleukin-4 was produced compared to interleukin-5.
Gene_expression (produced) of interleukin-5
12) Confidence 0.44 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.32 Pain Relevance 0.22
A mathematical model published before was applied [27] and the relative expression ratio was calculated from the real-time PCR efficiencies and the crossing point deviation of an unknown sample versus a control Ct IL-5 represents cycles when IL-5 expression is augmented; Ct Ract represents cycles when R actine expression is augmented (control); Ct IL-5/Ct Ract represents ratio.
Gene_expression (expression) of IL-5
13) Confidence 0.42 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0 Pain Relevance 0.07
Since cell profile in airway resulted in amelioration of eosinophils and levels of IL-5 in airways when highest doses of ATRA (2,500 ug every second day) were applied in mice, we then were interested in investigating if studies of airway function in vivo was affected.
Gene_expression (levels) of IL-5 in eosinophils
14) Confidence 0.42 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0 Pain Relevance 0
To evaluate the effects of beta-escin on cytokine secretion, the levels of IL-5 and IL-13 were determined in BALF supernatants of individual mice from each group.
Gene_expression (levels) of IL-5 associated with cytokine
15) Confidence 0.41 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.52 Pain Relevance 0.30
Thus, the overall pattern of results for cellular infiltration and the levels of the pro-inflammatory cytokines, IL-4, IL-5 and TNF-?
Gene_expression (levels) of IL-5 associated with inflammation and cytokine
16) Confidence 0.41 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 1.13 Pain Relevance 0.72
Levels of IL-5 were significantly (p < 0.05) higher in OVA challenged mice compared to the non-OVA-challenged mice (Figure 2C, Table 4) and in mice receiving Dexamethasone.
Gene_expression (Levels) of IL-5 associated with dexamethasone
17) Confidence 0.41 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0 Pain Relevance 0.11
Asshown in Figure 7, IL-4, IL-5, IL-13, IgE productions in
Gene_expression (productions) of IL-5
18) Confidence 0.40 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.22 Pain Relevance 0.13
supernatants were collected, and the productions of IL-4, IL-5, IL-10, IL-13, IgE, histamine
Gene_expression (productions) of IL-5
19) Confidence 0.40 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.27 Pain Relevance 0.13
on IL-4, IL-5, IL-10, and IL-13 production may have involved reduced production of IL-4, IL-5, IL-13,
Gene_expression (production) of IL-5
20) Confidence 0.40 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.20 Pain Relevance 0.04

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