INT20381

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Context Info
Confidence 0.77
First Reported 1988
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 71
Total Number 74
Disease Relevance 34.23
Pain Relevance 13.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 15
spleen 5
thymocytes 4
lymphocytes 3
NK cells 3
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 738 100.00 Very High Very High Very High
rheumatoid arthritis 159 99.26 Very High Very High Very High
Opioid 10 99.24 Very High Very High Very High
Morphine 26 99.12 Very High Very High Very High
anesthesia 31 98.86 Very High Very High Very High
agonist 84 98.80 Very High Very High Very High
COX2 5 98.74 Very High Very High Very High
cocaine 20 98.64 Very High Very High Very High
alcohol 35 98.16 Very High Very High Very High
antagonist 28 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 813 100.00 Very High Very High Very High
Necrosis 29 100.00 Very High Very High Very High
Disease 548 99.84 Very High Very High Very High
Communicable Diseases 5 99.58 Very High Very High Very High
Autoimmune Disease 184 99.36 Very High Very High Very High
Rheumatoid Arthritis 217 99.26 Very High Very High Very High
Pneumonia 119 98.36 Very High Very High Very High
Hyperglycemia 8 98.04 Very High Very High Very High
Sprains And Strains 187 97.96 Very High Very High Very High
Pulmonary Disease 60 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes.
Localization (secretion) of interleukin-2 associated with cox2
1) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15284281 Disease Relevance 0.17 Pain Relevance 0.22
Collectively, the aforementioned studies suggest that inhibition of interleukin-2 secretion by anandamide is independent of CB1/CB2 and the AMT/FAAH system.
Localization (secretion) of interleukin-2
2) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.05
Moreover, NS398 [N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide], a cyclooxygenase-2-specific inhibitor, also attenuated the inhibitory effects of anandamide and arachidonic acid upon interleukin-2 secretion.
Localization (secretion) of interleukin-2
3) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.05
Interestingly, arachidonic acid caused a concentration-dependent inhibition of interleukin-2 secretion (IC(50) = 10.3 microM), which was similar to that of structurally related anandamide (IC(50) = 11.4 microM).
Localization (secretion) of interleukin-2
4) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0.12 Pain Relevance 0.15
Finally, pretreatment with a peroxisome proliferator-activated receptor gamma (PPARgamma)-specific antagonist, T0070907 [2-chloro-5-nitro-N-4-pyridinyl-benzamide], partially antagonized anandamide-mediated suppression of IL-2 secretion.
Localization (secretion) of IL-2 associated with antagonist
5) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.05
Oncomice thymocytes released less sIL-2R than FVB thymocytes.
Localization (released) of IL-2 in thymocytes
6) Confidence 0.73 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.24 Pain Relevance 0.47
The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice splenocytes and thymocytes depended on the presence of the oncogene product, on the in vivo pretreatment with alcohol, or on the in vitro treatment with cocaine or morphine.
Localization (release) of IL-2 in thymocytes associated with morphine, cocaine and alcohol
7) Confidence 0.68 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.26 Pain Relevance 0.32
Parallel bioassays showed that secreted IL-2/IL-4 activity levels and mRNA levels correlated well for all clones.
Localization (secreted) of IL-2
8) Confidence 0.61 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 8381052 Disease Relevance 0.23 Pain Relevance 0.09
Dependence on PGE2 for this response was not found in all clones, as some TH1 cells could produce GM-CSF after IL-2 alone, and some cells did not produce GM-CSF even in the presence of PGE2 and IL-2.
Localization (presence) of IL-2 associated with addiction
9) Confidence 0.61 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.08 Pain Relevance 0.05
Activation of melatonin receptors enhances the release of Th cell cytokines, such as gamma-interferon and interleukin-2, as well as novel opioid cytokines which cross-react immunologically with both interleukin-4 and dynorphin B.
Localization (release) of interleukin-2 associated with dynorphin, opioid and cytokine
10) Confidence 0.53 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 9266542 Disease Relevance 0.31 Pain Relevance 0.35
One possibility as to why IL-2 neutralization was not 100% effective in preventing disease (reaching 62%, see Table 1) could be due to the additional depletion of Tregs.
Localization (neutralization) of IL-2 associated with disease
11) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.30 Pain Relevance 0.15
As in the case of IL-2 and IFN-?
Localization (case) of IL-2
12) Confidence 0.50 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0 Pain Relevance 0
The results of assays of IL-2 and IFN-?
Localization (assays) of IL-2
13) Confidence 0.50 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0 Pain Relevance 0
However, cells cultured with Con A produced significant amounts of IL-2 and IFN-?.
Localization (amounts) of IL-2
14) Confidence 0.50 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0 Pain Relevance 0
In agreement with these results, we found that IL-2 neutralization blocked the migration of donor CD8+ T cells into the pancreas in 50% of mice analyzed at day 13 post transfer and reduced the number of infiltrating cells in the remaining mice (Fig. 3C).
Localization (neutralization) of IL-2 in pancreas
15) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.54 Pain Relevance 0
The effect of deltorphin and DAME on secretion of the T cell growth factor, IL-2, was determined by ELISA analysis of supernatants obtained from CD4+ T cells after 48-hr culture.
Localization (secretion) of IL-2 in T cells
16) Confidence 0.47 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791081 Disease Relevance 0 Pain Relevance 0.13
Deltorphin showed a biphasic effect: 10(-11) M enhanced IL-2 secretion, whereas higher concentrations (10(-9)-10(-7) M) were inhibitory.
Localization (secretion) of IL-2
17) Confidence 0.47 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791081 Disease Relevance 0 Pain Relevance 0.07
Sera from 3 renal allograft recipients treated with OKT3 were studied and showed that a massive although transient release of some cytokines namely, Tumor Necrosis Factor alpha, Interleukin 2 and Interferon gamma is observed following the first OKT3 injection.
Localization (release) of Interleukin 2 associated with necrosis, cancer and cytokine
18) Confidence 0.45 Published 1988 Journal C. R. Acad. Sci. III, Sci. Vie Section Abstract Doc Link 3146414 Disease Relevance 0.76 Pain Relevance 0.14
The proliferative capacity of the splenocytes, as well as their ability to release IL-2 and IL-3, was significantly depressed in the vehicle-treated hemorrhaged animals, compared to shams.
Localization (release) of IL-2
19) Confidence 0.43 Published 1996 Journal J. Surg. Res. Section Abstract Doc Link 8661172 Disease Relevance 0.39 Pain Relevance 0.25
Two hours following saline or prolactin injection, splenocytes (SPL) were harvested and assessed for proliferative capacity (PC) and their ability to release IL-2 and IL-3.
Localization (release) of IL-2
20) Confidence 0.43 Published 1996 Journal J. Surg. Res. Section Abstract Doc Link 8661172 Disease Relevance 0.36 Pain Relevance 0.25

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