INT203816

Context Info Confidence 0.75 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.37 Pain Relevance 0.40

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency skeletal muscle 1 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Potency 104 89.20 Substantia nigra 8 58.16 Ventral tegmentum 8 54.88 midbrain 15 51.12 Dopamine 115 50.00 Eae 7 5.00 Dynorphin 6 5.00 monoamine 3 5.00 Serotonin 3 5.00 dopamine receptor 3 5.00

Disease Link Frequency Relevance Heat Sprains And Strains 4 92.80 Toxicity 57 91.36 Hepatotoxicity 78 87.80 Apoptosis 50 81.84 Injury 7 80.52 Body Weight 17 78.24 Targeted Disruption 20 73.16 Obesity 1 45.28 Weight Loss 10 44.72 Hypertrophy 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sections were incubated with a mouse monoclonal anti PTEN (Cell Signaling, Danvers, MA) or with anti p-AKT rabbit monoclonal antibody (1?

Localization (antibody) of PTEN

1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.13

Unlike Wijesekara et al, we found very little PTEN in wild type skeletal muscle [23].

Localization (found) of PTEN in skeletal muscle

2) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.51 Pain Relevance 0

Three active ASO sequences (6, 8 and 9, Table 1) targeting either mouse ApoB or mouse PTEN were identified in cell culture assays using methods previously described for these targets.

Localization (targeting) of PTEN

3) Confidence 0.26 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.49 Pain Relevance 0.13

ASOs targeting murine PTEN were dosed at 0.083–2.25 ?

Localization (targeting) of PTEN

4) Confidence 0.26 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.37 Pain Relevance 0.14

General Comments

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