INT20382

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Context Info
Confidence 0.66
First Reported 1990
Last Reported 2011
Negated 5
Speculated 4
Reported most in Body
Documents 211
Total Number 217
Disease Relevance 142.26
Pain Relevance 51.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
T cells 26
lung 13
lymphocytes 10
Th2 cells 7
blood 6
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6291 100.00 Very High Very High Very High
Inflammation 5988 100.00 Very High Very High Very High
chemokine 1491 100.00 Very High Very High Very High
Inflammatory response 436 100.00 Very High Very High Very High
agonist 612 99.82 Very High Very High Very High
mu opioid receptor 6 99.80 Very High Very High Very High
narcan 14 99.42 Very High Very High Very High
Central nervous system 390 99.36 Very High Very High Very High
Catecholamine 8 99.24 Very High Very High Very High
antagonist 1278 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 6376 100.00 Very High Very High Very High
Colitis 213 100.00 Very High Very High Very High
Asthma 9977 99.98 Very High Very High Very High
Hypersensitivity 1216 99.98 Very High Very High Very High
Eosinophilia 622 99.90 Very High Very High Very High
Systemic Lupus Erythematosus 557 99.84 Very High Very High Very High
Chronic Sinusitis 44 99.84 Very High Very High Very High
Adhesions 324 99.80 Very High Very High Very High
Targeted Disruption 972 99.78 Very High Very High Very High
Multiple Sclerosis 1154 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhalation of APC significantly inhibited the expression of T helper 2 (Th2) cytokines, immunoglobulin E (IgE), eosinophilic inflammation, and hyperresponsiveness.
Gene_expression (expression) of Th2 associated with rhinitis, inflammation and cytokine
1) Confidence 0.66 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.99 Pain Relevance 0.45
APC also significantly suppressed the expression of Th2 cytokines and IgE from lymphocytes isolated from OVA-sensitized/challenged animals.
Gene_expression (expression) of Th2 in lymphocytes associated with cytokine
2) Confidence 0.57 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.94 Pain Relevance 0.47
Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice.
Gene_expression (expression) of Th2 associated with cytokine
3) Confidence 0.57 Published 2004 Journal Blood Section Title Doc Link 14604971 Disease Relevance 0.94 Pain Relevance 0.42
Upon OVA allergen challenge, sensitized WT mice displayed robust allergic inflammatory responses, including macrophage and eosinophil dominated cell infiltration in the airway and in the lung parenchyma, goblet cell hyperplasia, OVA-specific IgE and IgG1 production, and Th2 cytokine production in the lung.
Gene_expression (production) of Th2 in lung associated with inflammatory response, hypersensitivity, hyperplasia and cytokine
4) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.68 Pain Relevance 0.23
In the present paper, the expression of PPNK mRNA in purified CD4+ Th1 and Th2 lymphocyte subpopulations is investigated and correlated with the presence of the opioid neuropeptides leu- and met-enkephalin.
Spec (investigated) Gene_expression (expression) of Th2 in lymphocyte associated with neuropeptide, enkephalin and opioid
5) Confidence 0.55 Published 1999 Journal Immunol. Cell Biol. Section Abstract Doc Link 10540203 Disease Relevance 0 Pain Relevance 0.36
Furthermore, evidence suggests that endocannabinoids have immunosuppressant and anti-inflammatory properties, they downregulate the production of T helper 1 (Th1) cytokines, enhancing the production of T helper 2 (Th2) cytokines, since a polarization of T cell response towards a Th2 phenotype has been associated with therapeutic benefit in MS, while a shift towards Th1 has been associated with disease progression (Matsuda et al 1990; Hemmer 2002).
Gene_expression (production) of Th2 in T cell associated with endocannabinoid, multiple sclerosis, inflammation, disease progression and cytokine
6) Confidence 0.53 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.83 Pain Relevance 0.82
We have cloned CD4+ T cells against a male transplantation Ag that, unlike Th1 or Th2 clones, suppresses the rejection of male skin grafts and are therefore considered examples of regulatory T cells.
Gene_expression (suppresses) of Th2 in skin
7) Confidence 0.52 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801640 Disease Relevance 0.10 Pain Relevance 0.06
Regulatory T cells overexpress a subset of Th2 gene transcripts.
Gene_expression (overexpress) of Th2 in Regulatory T cells
8) Confidence 0.52 Published 2002 Journal J. Immunol. Section Title Doc Link 11801640 Disease Relevance 0.09 Pain Relevance 0.10
We have identified, using serial analysis of gene expression, transcripts that are overexpressed in regulatory T cells compared with Th1 and Th2 clones.
Gene_expression (overexpressed) of Th2 in regulatory T cells
9) Confidence 0.52 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801640 Disease Relevance 0.09 Pain Relevance 0.11
Recently, we found, using a murine model, that restraint causing psychological stress exacerbates allergen-induced airway inflammation and Th2 cytokine expression via MOR in the central nervous system.
Gene_expression (expression) of Th2 in central nervous system associated with stress, inflammation, mu opioid receptor, central nervous system and cytokine
10) Confidence 0.47 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20408448 Disease Relevance 1.24 Pain Relevance 0.65
Thus the oxazolone-induced colitis is a suitable model of colitis for evaluation of the CIITA effect on IL-4 production and Th2 inflammation in vivo that has features resembling the human disease, ulcerative colitis.
Gene_expression (production) of Th2 associated with colitis, inflammatory bowel disease, inflammation and disease
11) Confidence 0.47 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.52 Pain Relevance 0.28
Th2 cytokines (IL-4, IL-13) were significantly increased from 4 h to day 7. 5-HT-expressing cells in the intestine were increased from day 1 to day 7.
Gene_expression (expressing) of Th2 in intestine
12) Confidence 0.46 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 19735478 Disease Relevance 0.07 Pain Relevance 0
We found that cardiac Th cytokine responses after burn were specific for Th-17, as cardiac levels of Th-1 (IFN-?)
Gene_expression (levels) of Th-2 associated with burns and cytokine
13) Confidence 0.46 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 0.98 Pain Relevance 0.33
Exogenous leptin administration in sensitized mice increased allergen-induced increases in airway responsiveness and serum IgE without any effects on airway inflammation or TH2 cytokine expression (Shore et al. 2005).
Gene_expression (expression) of TH2 associated with inflammation and cytokine
14) Confidence 0.44 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 1.63 Pain Relevance 0.21
Airway and lung inflammation, immunoglobulin response, Th2 cytokine production and lymphocyte response were analyzed and compared with wild type mice.
Gene_expression (production) of Th2 in lymphocyte associated with inflammation, pneumonia and cytokine
15) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2994819 Disease Relevance 0.51 Pain Relevance 0.22
This is paradoxical with the observation that OVA induced Th2 cytokine production and allergic inflammatory response was significantly reduced in p110?
Gene_expression (production) of Th2 associated with inflammatory response, hypersensitivity and cytokine
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.30 Pain Relevance 0.17
In contrast, mite allergen treatment induced the expression of T helper 2 (TH2)-type cytokines, including IL-4, IL-5, IL-13, and RANTES, compared with no treatment or saline treatment, whereas maternal exposure to DEHP during neonatal periods did not significantly enhance the effects (data not shown).
Gene_expression (expression) of TH2 associated with cytokine
17) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535612 Disease Relevance 0.46 Pain Relevance 0.05
However, the results were contradictory to the report that CIITA functioned to suppress the production of Th2 cytokine by CD4+ T cells in CIITA deficient mice.
Gene_expression (production) of Th2 in T cells associated with cytokine
18) Confidence 0.42 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721999 Disease Relevance 0.70 Pain Relevance 0.05
We present evidence that these effects could be mediated by the modulation of Th1/Th2 cytokine production.
Gene_expression (production) of Th2 associated with cytokine
19) Confidence 0.42 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.06 Pain Relevance 0.67
agonists have the potential to shift the T-cell response from Th2 to Th1, or to reduce Th2 cytokine expression, which may be of therapeutic benefit in ASD.
Gene_expression (expression) of Th2 in T-cell associated with agonist and cytokine
20) Confidence 0.41 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.37 Pain Relevance 0.33

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