INT203848

Context Info Confidence 0.06 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0.20

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Pten (Mus musculus) Lna1 (Mus musculus)

Pain Link Frequency Relevance Heat Potency 52 100.00 anesthesia 1 5.00 Inflammation 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Hepatotoxicity 39 77.88 Body Weight 8 70.64 Apoptosis 20 63.44 Rhinitis 2 61.12 Reprotox - General 2 1 39.28 Toxicity 28 27.28 Weight Loss 5 5.00 Reprotox - General 1 3 5.00 Injury 3 5.00 Death 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results clearly demonstrate the ability to improve potency with some, but not all, LNA containing ASO designs, particularly for the TRADD and PTEN targets.

PTEN Binding (improve) of LNA associated with potency

1) Confidence 0.06 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.40 Pain Relevance 0.20

General Comments

This test has worked.