INT20388

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Context Info
Confidence 0.39
First Reported 1988
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 5.65
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LYZ) hydrolase activity, acting on glycosyl bonds (LYZ) extracellular region (LYZ)
Anatomy Link Frequency
histiocytes 1
monocytes 1
leukocyte 1
pancreas 1
platelet 1
LYZ (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 99.42 Very High Very High Very High
Chronic pancreatitis 4 96.84 Very High Very High Very High
Inflammation 6 95.28 Very High Very High Very High
Enkephalin 1 94.56 High High
Paracetamol 3 94.40 High High
Analgesic 1 88.12 High High
tolerance 1 87.76 High High
imagery 1 76.48 Quite High
fifth nerve 4 75.00 Quite High
cva 1 73.64 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 4 99.40 Very High Very High Very High
Alzheimer's Dementia 1 99.20 Very High Very High Very High
Epstein-barr Virus 7 97.36 Very High Very High Very High
Pancreatitis 4 96.84 Very High Very High Very High
Plasma Cell Granuloma 6 95.28 Very High Very High Very High
Carcinoma 7 95.16 Very High Very High Very High
Cancer 51 94.20 High High
Confusion 2 92.84 High High
Hemorrhage 2 90.08 High High
Necrosis 10 86.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, renal selective targeting of the NSAID naproxen can be obtained by conjugation with the LMWP lysozyme.
LMWP lysozyme Binding (conjugation) of associated with cinod
1) Confidence 0.39 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9407519 Disease Relevance 0 Pain Relevance 0.10
Second, the effect of lysozyme conjugation on the body distribution of naproxen was studied.
lysozyme Binding (conjugation) of in body
2) Confidence 0.33 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9407519 Disease Relevance 0.07 Pain Relevance 0.13
In addition, lysozyme reactivity was absent in normal pancreas; however, lysozyme was expressed in one case of chronic pancreatitis, 17 cases of primary carcinoma, and three cases of metastatic carcinoma.
lysozyme Binding (reactivity) of in pancreas associated with carcinoma and chronic pancreatitis
3) Confidence 0.30 Published 1990 Journal Cancer Section Abstract Doc Link 2224768 Disease Relevance 1.19 Pain Relevance 0.37
It showed immunopositivity for leukocyte common antigen (LCA) and immunonegativity for S-100 and lysozyme.
lysozyme Binding (immunonegativity) of in leukocyte
4) Confidence 0.29 Published 2006 Journal J. Neurooncol. Section Abstract Doc Link 16132497 Disease Relevance 0.86 Pain Relevance 0.37
Gpp(NH)p, a GTPase insensitive analog of GTP, also inhibited the binding of FMLP but, paradoxically, enhanced superoxide anion generation and lysozyme release.
lysozyme Binding (binding) of
5) Confidence 0.23 Published 1990 Journal Inflammation Section Abstract Doc Link 2138998 Disease Relevance 0.15 Pain Relevance 0.82
The scope of investigations included in vitro tests such as the determination of protein binding, the inhibition of complement, lysozyme, urokinase, platelet aggregation, the release of histamine, the influence on thromboplastin time.
lysozyme Binding (binding) of in platelet
6) Confidence 0.09 Published 1994 Journal Arzneimittelforschung Section Abstract Doc Link 7529504 Disease Relevance 0.09 Pain Relevance 0.04
The neoplastic cells demonstrated immunohistochemical staining characteristics similar to those of normal monocytes/histiocytes, namely strong immunoreactivity with CD163, CD68, lysozyme, NSE, and vimentin.
lysozyme Binding (immunoreactivity) of in histiocytes
7) Confidence 0.08 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.59 Pain Relevance 0
The neoplastic cells demonstrated immunohistochemical staining characteristics similar to those of normal monocytes/histiocytes, namely strong immunoreactivity with CD163, CD68, lysozyme, NSE, and vimentin.
lysozyme Binding (immunoreactivity) of in monocytes
8) Confidence 0.03 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.59 Pain Relevance 0
In contrast the low-molecular-weight CPIs were present in postmicrosomal fractions (S3) and cross-reacted with anti-cystatin c, but not with anti-HRG, anti-lysozyme, anti-beta protein amyloid peptide, or anti-T-kininogen.
anti-lysozyme Binding (cross-reacted) of associated with alzheimer's dementia
9) Confidence 0.01 Published 1988 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3265047 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

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