INT20392

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Context Info
Confidence 0.04
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FPR1) signal transduction (FPR1) plasma membrane (FPR1)
signal transducer activity (FPR1)
FPR1 (Homo sapiens)
CR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 86.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that piroxicam and indomethacin inhibit FMLP receptor-mediated upregulation of CD11b, CD11c, and CD35 in PMNs, but have no effect on the upregulation of these molecules by ionomycin or C5a.
FMLP Positive_regulation (upregulation) of CD35
1) Confidence 0.04 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.07 Pain Relevance 0.06
Both piroxicam and indomethacin inhibited FMLP-induced upregulation of CD11b, CD11c, and CD35, but neither drug affected the upregulation of these surface molecules induced by C5a or ionomycin.
FMLP Positive_regulation (upregulation) of CD35
2) Confidence 0.03 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.14 Pain Relevance 0.16

General Comments

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