INT20394

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Context Info
Confidence 0.06
First Reported 1990
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 5.47
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce)
cytoplasm (Tbce)
Anatomy Link Frequency
lung 3
PMN 2
poly 1
fungal cells 1
phagocyte 1
Tbce (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 7 100.00 Very High Very High Very High
cytokine 104 99.92 Very High Very High Very High
cINOD 2 99.80 Very High Very High Very High
orphanin 8 99.08 Very High Very High Very High
opioid receptor 1 96.40 Very High Very High Very High
Inflammation 116 95.44 Very High Very High Very High
Pain 13 94.96 High High
Inflammatory response 33 94.40 High High
Restless leg syndrome 1 77.60 Quite High
aspirin 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 7 100.00 Very High Very High Very High
INFLAMMATION 106 99.52 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 84 99.32 Very High Very High Very High
Infection 42 97.64 Very High Very High Very High
Pneumonia 63 96.52 Very High Very High Very High
Atypical Pneumonia 8 95.76 Very High Very High Very High
Lung Injury 41 94.96 High High
Pain 13 94.96 High High
Hyperoxia 8 93.36 High High
Sprains And Strains 114 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of polymorph nuclear neutrophils (PMN) in limb ischemia and reperfusion has been recognized only in recent years.
PMN Binding (recognized) of in PMN associated with ischemia
1) Confidence 0.06 Published 1998 Journal Vasc Med Section Abstract Doc Link 9892509 Disease Relevance 0.39 Pain Relevance 0.19
Both MyD88-dependent and MyD88-independent pathways were required for maximal PMN recruitment and vascular permeability resulting from the combination of mechanical ventilation and poly(I:C) treatment.


PMN Binding (recruitment) of in poly
2) Confidence 0.05 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.15 Pain Relevance 0.19
Mechanical ventilation augments PMN recruitment, cytokine expression, and lung permeability in murine models of Staphylococcus aureus pneumonia [11] and viral pneumonia [12].
PMN Binding (recruitment) of in lung associated with atypical pneumonia, pneumonia and cytokine
3) Confidence 0.05 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 1.41 Pain Relevance 0.25
Compared with the instillation of HCl, LPS caused more prominent alveolar destruction, greater alveolar recruitment of PMN, and more severe alveolar exudates.
PMN Binding (recruitment) of
4) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.78 Pain Relevance 0.07
The first set of experiments demonstrated that mechanical ventilation augments TLR3-induced cytokine production, PMN recruitment, and lung permeability via one or more MyD88-dependent pathways.
PMN Binding (recruitment) of in lung associated with cytokine
5) Confidence 0.05 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.30 Pain Relevance 0.21
Selective attenuation of the mechanical ventilation effect on cytokine expression, PMN recruitment, and lung permeability in MyD88-/- mice suggests a role for signaling via the MyD88 adapter protein in ventilator-associated lung injury.
PMN Binding (recruitment) of in lung associated with lung injury and cytokine
6) Confidence 0.05 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.39 Pain Relevance 0.16
Human PMN express mRNA for Noci-R, its nucleotide sequence determined, and specific binding with [(125)I]-labeled nociceptin gave an apparent K(d) approximately 1.5 nM for this PMN opioid receptor.
PMN Spec (determined) Binding (binding) of in PMN associated with orphanin and opioid receptor
7) Confidence 0.03 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11238602 Disease Relevance 0.09 Pain Relevance 0.54
C. gattii┬ľPMN interactions
PMN Binding (interactions) of
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881863 Disease Relevance 0.05 Pain Relevance 0
We have previously shown that in vitro interactions between human PMN and C. gattii can be used for a complimentary evaluation of virulence outcome in mouse models, and to assess the likely outcome of initial interactions between C. gattii and phagocyte cells [10], [29], [31].
PMN Binding (interactions) of in phagocyte
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881863 Disease Relevance 0.05 Pain Relevance 0
Further experiments focused on interactions between fungal cells and human phagocytes (PMN), to elucidate the factors that determine if the pathogen persists or is eliminated from the host.


PMN Binding (interactions) of in fungal cells
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881863 Disease Relevance 0.33 Pain Relevance 0
By SEM, we further examined roles of C. gattii extracellular fibrils in PMN interactions.
PMN Spec (examined) Binding (interactions) of
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881863 Disease Relevance 0.52 Pain Relevance 0
SEM analysis of C. gattii-PMN interactions were carried using Thermanox® plastic cover slips in 24-well flat-bottom tissue culture plates.
PMN Binding (interactions) of
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881863 Disease Relevance 0.27 Pain Relevance 0
The PMN in these interactions had rudimentary NETs while C. gattii cells from YPD agar formed a few extracellular fibrils.
PMN Binding (interactions) of associated with tumor necrosis factor receptor-associated periodic syndrome
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881863 Disease Relevance 0.58 Pain Relevance 0
Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit PMN aggregation, chemotaxis, degranulation, and superoxide anion production stimulated by synthetic formyl peptides.
PMN Neg (inhibit) Binding (aggregation) of associated with inflammation and cinod
14) Confidence 0.00 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.17 Pain Relevance 0.17

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