INT20396

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Context Info
Confidence 0.22
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.01
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgax)
Anatomy Link Frequency
myeloid cells 2
neutrophils 2
Itgax (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 6 95.28 Very High Very High Very High
Central nervous system 32 84.24 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 15 99.84 Very High Very High Very High
Infection 31 98.32 Very High Very High Very High
Neurocysticercosis 23 74.60 Quite High
Central Nervous System Disease 28 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Autoimmune Disease 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Brain Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, infiltrating CD11b and CD11c positive myeloid cells predominantly produced TLR11 protein, particularly early during infection at 1 wk post infection (~50% cells).
Negative_regulation (produced) of Positive_regulation (infiltrating) of CD11c in myeloid cells associated with infection
1) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2631477 Disease Relevance 0.54 Pain Relevance 0.11
Furthermore, piroxicam had no effect on 37 degrees C-induced upregulation of any of the surface proteins, while indomethacin showed no effect on 37 degrees C-induced CD11b upregulation but suppressed CD11c and CD35 upregulation.
Negative_regulation (suppressed) of Positive_regulation (upregulation) of CD11c
2) Confidence 0.06 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.13 Pain Relevance 0.13
Nonsteroidal antiinflammatory agents inhibit upregulation of CD11b, CD11c, and CD35 in neutrophils stimulated by formyl-methionine-leucine-phenylalanine.
Negative_regulation (inhibit) of Positive_regulation (upregulation) of CD11c in neutrophils associated with inflammation
3) Confidence 0.06 Published 1990 Journal Inflammation Section Title Doc Link 2138999 Disease Relevance 0.20 Pain Relevance 0.17
Both piroxicam and indomethacin inhibited FMLP-induced upregulation of CD11b, CD11c, and CD35, but neither drug affected the upregulation of these surface molecules induced by C5a or ionomycin.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of CD11c
4) Confidence 0.06 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.15 Pain Relevance 0.16

General Comments

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