INT204000

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per2) nucleus (Per2) protein binding transcription factor activity (Per2)
cytoplasm (Per2) signal transducer activity (Per2)
Per2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 75 50.00 Quite Low
gABA 129 16.20 Low Low
antagonist 29 5.00 Very Low Very Low Very Low
agonist 28 5.00 Very Low Very Low Very Low
Neurotransmitter 26 5.00 Very Low Very Low Very Low
Glutamate 13 5.00 Very Low Very Low Very Low
Action potential 13 5.00 Very Low Very Low Very Low
GABAergic 13 5.00 Very Low Very Low Very Low
tetrodotoxin 9 5.00 Very Low Very Low Very Low
GABA receptor 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 14 97.36 Very High Very High Very High
Repression 3 76.96 Quite High
Targeted Disruption 7 63.92 Quite High
Manic Depressive Disorder 7 50.00 Quite Low
Ganglion Cysts 26 5.00 Very Low Very Low Very Low
Bronchopulmonary Dysplasia 18 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Affective Disorder 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the limited resolution of the in vivo data (4-h intervals) prevented a more precise definition of the expected delay between Per2 transcription and PER2::LUC luminescence.
Negative_regulation (prevented) of Transcription (transcription) of Per2
1) Confidence 0.37 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0
As previously described, mPer2 transcription in wildtype MEFs peaked at TP24, following the initial transcriptional response to serum shock at TP1 (Fig. 5A,D).
Negative_regulation (peaked) of Transcription (transcription) of mPer2 associated with shock
2) Confidence 0.21 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.46 Pain Relevance 0

General Comments

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