INT204006

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.66
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
brain 4
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 67 99.32 Very High Very High Very High
Arthritis 2 98.84 Very High Very High Very High
Inflammation 3 97.20 Very High Very High Very High
Dopamine 11 96.76 Very High Very High Very High
corticosteroid 45 52.64 Quite High
amygdala 6 43.44 Quite Low
Hippocampus 21 42.24 Quite Low
rheumatoid arthritis 5 35.52 Quite Low
medulla 9 34.80 Quite Low
Neurotransmitter 12 32.16 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 2 98.84 Very High Very High Very High
Colitis 1 98.28 Very High Very High Very High
Disease 12 97.56 Very High Very High Very High
INFLAMMATION 3 97.20 Very High Very High Very High
Anxiety Disorder 63 90.96 High High
Attention Deficit Hyperactivity Disorder 15 90.36 High High
Prostate Cancer 7 89.92 High High
Cognitive Disorder 24 83.80 Quite High
Shock 41 78.92 Quite High
Cancer 11 73.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective inhibition of GSK3 by kenpaullone lengthens mPer2 period
Negative_regulation (inhibition) of Localization (Selective) of GSK3
1) Confidence 0.40 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0 Pain Relevance 0
A similar behavior in the FST was observed in mice harboring a deletion of one allele of GSK-3?
Negative_regulation (deletion) of Localization (allele) of GSK-3 associated with eae
2) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.36 Pain Relevance 0.37
Our studies revealed an increase in cerebellar volume, but normal brain volume in GSK-3?
Negative_regulation (revealed) of Localization (volume) of GSK-3 in brain
3) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.33 Pain Relevance 0.03
Our studies revealed an increase in cerebellar volume, but normal brain volume in GSK-3?
Negative_regulation (brain) of Localization (volume) of GSK-3 in brain
4) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.32 Pain Relevance 0.03
While mutation of these residues leads to a reduction of phosphorylation and an increase in BMAL1 stability, we predict the presence of additional GSK3?
Negative_regulation (predict) of Localization (presence) of GSK3
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0.03
The second well-defined mechanism of GSK3?
Negative_regulation (defined) of Localization (mechanism) of GSK3
6) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650783 Disease Relevance 0.65 Pain Relevance 0.15

General Comments

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