INT204009

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.57
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per2) nucleus (Per2) protein binding transcription factor activity (Per2)
cytoplasm (Per2) signal transducer activity (Per2)
Anatomy Link Frequency
retina 2
Per2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 13 98.80 Very High Very High Very High
Neurotransmitter 26 96.64 Very High Very High Very High
Glutamate receptor 2 71.44 Quite High
antagonist 29 69.92 Quite High
Action potential 13 65.88 Quite High
imagery 7 52.88 Quite High
Dopamine 75 50.00 Quite Low
sodium channel 1 12.00 Low Low
tetrodotoxin 9 10.16 Low Low
gABA 129 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 26 93.36 High High
Repression 3 89.72 High High
Shock 14 76.12 Quite High
Targeted Disruption 7 73.04 Quite High
Manic Depressive Disorder 7 50.00 Quite Low
Bronchopulmonary Dysplasia 18 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Affective Disorder 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results indicate that the mouse retina requires neither normal levels of melatonin nor melatonin rhythmicity to maintain PER2::LUC rhythms.
Positive_regulation (requires) of PER2 Binding (maintain) of in retina
1) Confidence 0.43 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.21 Pain Relevance 0.38
Lithium lengthens mPer2 period and phenocopies GSK3 knockdown
Positive_regulation (lengthens) of mPer2 Binding (period) of
2) Confidence 0.21 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.36 Pain Relevance 0

General Comments

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