INT20401

Context Info Confidence 0.49 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 11 Disease Relevance 3.77 Pain Relevance 0.87

Anatomy Link Frequency FDC 1 neutrophils 1 CR1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 8 95.68 epidural 1 90.88 backache 1 87.76 cva 4 85.76 Inflammation 54 78.56 Pain 1 68.28 alcohol 9 5.00 eye pain 3 5.00 Nicotine 3 5.00 Inflammatory response 3 5.00

Disease Link Frequency Relevance Heat Cancer 13 99.76 INFLAMMATION 62 99.68 Targeted Disruption 28 99.28 Sprains And Strains 80 98.28 Epstein-barr Virus 3 94.72 Low Back Pain 1 87.76 Necrosis 1 86.28 Hemorrhage 1 85.76 Recurrence 2 81.56 Follicular Dendritic Cell Sarcoma 3 80.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The atypical cells were immunoreactive for FDC markers such as CD21/CD35, CD23, and CNA.42.

Positive_regulation (immunoreactive) of CD35 in FDC

1) Confidence 0.49 Published 2001 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11395549 Disease Relevance 1.59 Pain Relevance 0.22

Since there is no complete absence of CR1 among humans, to show the effect of complete absence of CR1 on invasion we compared the invasion of wild-type mouse red cells, which do not express CR1, and mouse transgenic red cells expressing human CR1.

Positive_regulation (absence) of CR1 associated with targeted disruption

2) Confidence 0.47 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.49 Pain Relevance 0

Interestingly, both sialic acid-independent and dependent strains showed increased invasion of CR1 transgenic mouse red cells but the latter seemed to require the intact sialic acid of glycophorin for optimal CR1-mediated invasion.

Positive_regulation (require) of CR1 associated with targeted disruption and sprains and strains

3) Confidence 0.47 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.56 Pain Relevance 0

Immunohistochemical staining revealed that the tumor cells were positive for CD21, CD23, CD35, and clusterin, and focally positive for CD68, CD20, and CD79a.

Positive_regulation (positive) of CD35 associated with cancer

4) Confidence 0.40 Published 2006 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 17076538 Disease Relevance 0.51 Pain Relevance 0.13

Membrane-bound CRegs (Fig. 1) include decay-accelerating factor (DAF, CD55), membrane co-factor protein (MCP, CD46), complement receptor 1 (CR1, CD35), and membrane inhibitor of reactive lysis (MIRL, CD59).

Positive_regulation (include) of CR1

5) Confidence 0.27 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0

Membrane-bound CRegs (Fig. 1) include decay-accelerating factor (DAF, CD55), membrane co-factor protein (MCP, CD46), complement receptor 1 (CR1, CD35), and membrane inhibitor of reactive lysis (MIRL, CD59).

Positive_regulation (include) of complement receptor 1

6) Confidence 0.27 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0

Nonsteroidal antiinflammatory agents inhibit upregulation of CD11b, CD11c, and CD35 in neutrophils stimulated by formyl-methionine-leucine-phenylalanine.

Positive_regulation (upregulation) of CD35 in neutrophils associated with inflammation

7) Confidence 0.22 Published 1990 Journal Inflammation Section Title Doc Link 2138999 Disease Relevance 0.20 Pain Relevance 0.18

Furthermore, piroxicam had no effect on 37 degrees C-induced upregulation of any of the surface proteins, while indomethacin showed no effect on 37 degrees C-induced CD11b upregulation but suppressed CD11c and CD35 upregulation.

Positive_regulation (upregulation) of CD35

8) Confidence 0.22 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.13 Pain Relevance 0.13

Both piroxicam and indomethacin inhibited FMLP-induced upregulation of CD11b, CD11c, and CD35, but neither drug affected the upregulation of these surface molecules induced by C5a or ionomycin.

Positive_regulation (upregulation) of CD35

9) Confidence 0.16 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.14 Pain Relevance 0.16

We conclude that piroxicam and indomethacin inhibit FMLP receptor-mediated upregulation of CD11b, CD11c, and CD35 in PMNs, but have no effect on the upregulation of these molecules by ionomycin or C5a.

Positive_regulation (upregulation) of CD35

10) Confidence 0.15 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.07 Pain Relevance 0.06

Membrane-bound CRegs (Fig. 1) include decay-accelerating factor (DAF, CD55), membrane co-factor protein (MCP, CD46), complement receptor 1 (CR1, CD35), and membrane inhibitor of reactive lysis (MIRL, CD59).

Positive_regulation (include) of CD35

11) Confidence 0.12 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0

General Comments

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