INT204012

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.51
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
muscle 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 57 92.56 High High
cytokine 4 83.84 Quite High
Inflammation 13 77.44 Quite High
Analgesic 3 71.04 Quite High
imagery 2 61.24 Quite High
cINOD 14 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 18 99.84 Very High Very High Very High
Stomach Cancer 23 99.60 Very High Very High Very High
Targeted Disruption 133 99.26 Very High Very High Very High
Sprains And Strains 99 99.08 Very High Very High Very High
Insulin Resistance 12 97.96 Very High Very High Very High
Cancer 113 97.64 Very High Very High Very High
Diabetes Mellitus 41 96.80 Very High Very High Very High
Shock 28 96.72 Very High Very High Very High
Impaired Glucose Tolerance 42 93.20 High High
Alagille Syndrome 22 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective inhibition of GSK3 by kenpaullone lengthens mPer2 period
Regulation (lengthens) of Negative_regulation (inhibition) of GSK3
1) Confidence 0.42 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0 Pain Relevance 0
KO animals is not a result of a direct effect of inactivation of GSK-3?
Regulation (effect) of Negative_regulation (inactivation) of GSK-3 associated with targeted disruption
2) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.22 Pain Relevance 0.07
Given the beneficial effects of GSK-3 inhibitors in obese and insulin resistant rodents [4], [6], [7], it would be interesting to determine the effects of GSK-3?
Regulation (effects) of Negative_regulation (inhibitors) of GSK-3 associated with obesity
3) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.46 Pain Relevance 0.08
KO animals, muscle insulin signaling was unaffected by the loss of GSK-3?.
Neg (unaffected) Regulation (unaffected) of Negative_regulation (loss) of GSK-3 in muscle associated with targeted disruption
4) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.99 Pain Relevance 0.09
Although the expression patterns of known core clock genes have been previously documented, the control phase relationships among selected clock components were established in wild-type MEFs for comparative purposes prior to the investigation of the effects of GSK3 deficiency on the clock mechanism.
Spec (investigation) Regulation (effects) of Negative_regulation (deficiency) of GSK3
5) Confidence 0.26 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.10 Pain Relevance 0.03
through the inhibition of GSK3?
Regulation (through) of Negative_regulation (inhibition) of GSK3
6) Confidence 0.20 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.56 Pain Relevance 0.12
Recently, it was reported that the response to lithium occurs via two levels of inhibition: a rapid, direct inhibition of GSK3?
Regulation (direct) of Negative_regulation (inhibition) of GSK3
7) Confidence 0.11 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.18 Pain Relevance 0

General Comments

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