INT204018

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 34
Disease Relevance 13.67
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
neurons 1
brain 1
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 140 99.00 Very High Very High Very High
Arthritis 5 98.52 Very High Very High Very High
Inflammation 58 96.88 Very High Very High Very High
Dopamine 36 96.12 Very High Very High Very High
depression 56 95.68 Very High Very High Very High
tolerance 138 93.92 High High
Hippocampus 52 93.28 High High
ischemia 20 92.68 High High
rheumatoid arthritis 10 86.24 High High
cerebral cortex 14 72.60 Quite High
Disease Link Frequency Relevance Heat
Aggression 65 100.00 Very High Very High Very High
Stress 150 99.98 Very High Very High Very High
Sprains And Strains 250 99.42 Very High Very High Very High
Targeted Disruption 459 99.28 Very High Very High Very High
Arthritis 5 98.52 Very High Very High Very High
Shock 100 98.16 Very High Very High Very High
Colitis 2 97.96 Very High Very High Very High
Prostate Cancer 14 97.76 Very High Very High Very High
Death 374 97.44 Very High Very High Very High
Disease 469 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective inhibition of GSK3 by kenpaullone lengthens mPer2 period
Localization (Selective) of GSK3
1) Confidence 0.71 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0 Pain Relevance 0
A similar behavior in the FST was observed in mice harboring a deletion of one allele of GSK-3?
Localization (allele) of GSK-3 associated with eae
2) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.36 Pain Relevance 0.37
The lower social interaction and aggressive behavior of GSK-3?
Localization (behavior) of GSK-3 associated with aggression
3) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.45 Pain Relevance 0.03
Previous studies have reported that GSK-3?
Localization (reported) of GSK-3
4) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.55 Pain Relevance 0.15
These results suggest that the alteration of GSK3?
Localization (alteration) of GSK3
5) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.52 Pain Relevance 0.03
Our studies revealed an increase in cerebellar volume, but normal brain volume in GSK-3?
Localization (volume) of GSK-3 in brain
6) Confidence 0.59 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.32 Pain Relevance 0.03
It is known that social behavior is affected by an animals sentiment (e.g. familiarity and comfort within a given situation) [101], hence, the increased sensitivity to stress observed in GSK-3?
Localization (observed) of GSK-3 associated with stress
7) Confidence 0.59 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.57 Pain Relevance 0.05
Here, we have employed tissue-specific deletion of GSK-3?
Localization (deletion) of GSK-3
8) Confidence 0.57 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017066 Disease Relevance 0.69 Pain Relevance 0.04
KO mice on the ICR genetic background, we observed that animals with a global deletion of GSK-3?
Localization (deletion) of GSK-3 associated with targeted disruption
9) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.40 Pain Relevance 0
Thus, based on these findings and considering the lack of effect of hepatic deletion of GSK-3?
Localization (deletion) of GSK-3
10) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.20 Pain Relevance 0.03
on glucose metabolism and led us to generate tissue-specific deletions of GSK-3?
Localization (deletions) of GSK-3
11) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.99 Pain Relevance 0.05
This result indicated strain-specific effects of genetic ablation of GSK-3?
Localization (ablation) of GSK-3 associated with sprains and strains
12) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.96 Pain Relevance 0.05
KO provoked enhanced insulin sensitivity and hepatic glucose metabolism, tissue-specific deletions of GSK-3?
Localization (deletions) of GSK-3 associated with targeted disruption
13) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.57 Pain Relevance 0
These observations led us to investigate which tissues are responsible for the phenotype observed in the GSK-3?
Localization (observed) of GSK-3
14) Confidence 0.57 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.10 Pain Relevance 0.12
Further illustrating the importance of GSK3?
Localization (importance) of GSK3
15) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0.16 Pain Relevance 0.04
The implication of GSK3?
Localization (implication) of GSK3
16) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0.27 Pain Relevance 0.09
While mutation of these residues leads to a reduction of phosphorylation and an increase in BMAL1 stability, we predict the presence of additional GSK3?
Localization (presence) of GSK3
17) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0.03
Consistent with recent reports for GSK3?
Localization (reports) of GSK3
18) Confidence 0.32 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.42 Pain Relevance 0
amount and its distribution do not appear to be affected by MPP+ treatment, we cannot rule out the possibility of a translocation of the active form of GSK-3?
Localization (translocation) of GSK-3
19) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.23 Pain Relevance 0.05
The translocation of GSK-3?
Localization (translocation) of GSK-3
20) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.31 Pain Relevance 0.04

General Comments

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