INT204019

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.23
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular region (C2)
Anatomy Link Frequency
nerve 2
posterior 1
C2 (Mus musculus)
Pain Link Frequency Relevance Heat
nerve block 6 100.00 Very High Very High Very High
Cervicogenic headache 38 97.66 Very High Very High Very High
Pain 61 96.92 Very High Very High Very High
headache 27 95.12 Very High Very High Very High
rheumatoid arthritis 14 95.00 High High
Arthritis 3 89.80 High High
Facet joint 16 85.44 High High
depression 6 77.36 Quite High
Spinal cord 14 64.80 Quite High
iatrogenic 2 56.48 Quite High
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 35 98.92 Very High Very High Very High
Infection 65 98.76 Very High Very High Very High
Autoimmune Disease 9 97.96 Very High Very High Very High
Diabetes Mellitus 4 97.68 Very High Very High Very High
Post-traumatic Headache 46 97.66 Very High Very High Very High
Pain 50 96.92 Very High Very High Very High
Sleep Disorders 14 96.56 Very High Very High Very High
Neck Pain 9 96.16 Very High Very High Very High
Rheumatoid Arthritis 17 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It therefore seems more probable that the development of autoimmunity in MRL mice is in part related to a functional deficiency in C4, similar to that seen in humans with deficiencies in early classical pathway components such as C1q, C2, and C4.
Negative_regulation (deficiencies) of C2 associated with autoimmune disease
1) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.55 Pain Relevance 0
Genetic deficiencies in the early components of the classical complement pathway (C1 inhibitor, C1q/r/s, C2, or C4) are some of the strongest risk factors for the development of SLE [1].
Negative_regulation (deficiencies) of C2 associated with systemic lupus erythematosus
2) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 1.43 Pain Relevance 0.08
Therefore, these estimates showed a pronounced decrease in genetic variability from patient C1 to patient C3 (C1>C2 > C3).
Negative_regulation (decrease) of C2
3) Confidence 0.10 Published 2010 Journal Virol J Section Body Doc Link PMC2940812 Disease Relevance 0.19 Pain Relevance 0.03
Intrapatient variability was lower in patient C2, while in patient C3 it was minimal, thus matching the order in which they underwent sedation and colonoscopy.
Negative_regulation (lower) of C2 associated with sleep disorders
4) Confidence 0.10 Published 2010 Journal Virol J Section Body Doc Link PMC2940812 Disease Relevance 0.50 Pain Relevance 0
This molecule inhibits C1r, C1s, C3 convertase, C5 convertase, and FD (Fujii and Hitomi 1981; Inagi et al 1991).
Negative_regulation (inhibits) of C5 convertase
5) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0
By removing the C1 and C2 lamina, surgeons may easily access a directly posterior or posterolateral lesion as long as it is visible.
Negative_regulation (removing) of C2 in posterior
6) Confidence 0.04 Published 2010 Journal Journal of Craniovertebral Junction and Spine Section Body Doc Link PMC2944856 Disease Relevance 0.06 Pain Relevance 0.03
By contrast, despite a similar peak in transcription at TP1, mPer2 transcriptional expression was blunted in amplitude and maintained near maximal levels between TP24 and TP28 and transcriptional repression in c2.1 was delayed until after TP28 (Fig. 5B,D), an effect consistent with previous results obtained by reducing GSK3 activity by shRNA, genetically or pharmacologically.
Negative_regulation (repression) of c2 associated with repression
7) Confidence 0.04 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.39 Pain Relevance 0
Some authors recommend that when the diagnosis of cervicogenic headache is suspected, attempts should be made to confirm the diagnosis with the objective tests of cervical facet block and C2 nerve diagnostic blocks (4, 8, 9).
Negative_regulation (blocks) of C2 in nerve associated with cervicogenic headache
8) Confidence 0.03 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693602 Disease Relevance 1.07 Pain Relevance 0.99
Bovim et al. reported that C2 nerve block seemed to be the most informative procedure and C4 and C5 nerve block was of little value in the work-up of cervicogenic headaches (9).
Negative_regulation (block) of C2 in nerve associated with nerve block, post-traumatic headache and headache
9) Confidence 0.03 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693602 Disease Relevance 0.92 Pain Relevance 0.97
Postoperative radiographs showed adequate reduction of C1 over C2 in 35 cases.
Negative_regulation (reduction) of C2
10) Confidence 0.03 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2995783 Disease Relevance 1.13 Pain Relevance 0.33

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