INT20402

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Context Info
Confidence 0.18
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neutrophils 2
CR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, piroxicam had no effect on 37 degrees C-induced upregulation of any of the surface proteins, while indomethacin showed no effect on 37 degrees C-induced CD11b upregulation but suppressed CD11c and CD35 upregulation.
Negative_regulation (suppressed) of Positive_regulation (upregulation) of CD35
1) Confidence 0.18 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.13 Pain Relevance 0.13
Nonsteroidal antiinflammatory agents inhibit upregulation of CD11b, CD11c, and CD35 in neutrophils stimulated by formyl-methionine-leucine-phenylalanine.
Negative_regulation (inhibit) of Positive_regulation (upregulation) of CD35 in neutrophils associated with inflammation
2) Confidence 0.18 Published 1990 Journal Inflammation Section Title Doc Link 2138999 Disease Relevance 0.20 Pain Relevance 0.18
Both piroxicam and indomethacin inhibited FMLP-induced upregulation of CD11b, CD11c, and CD35, but neither drug affected the upregulation of these surface molecules induced by C5a or ionomycin.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of CD35
3) Confidence 0.13 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.15 Pain Relevance 0.16

General Comments

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