INT20402

Context Info Confidence 0.18 First Reported 1990 Last Reported 1990 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0.47 Pain Relevance 0.46

Anatomy Link Frequency neutrophils 2 CR1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 6 95.68

Disease Link Frequency Relevance Heat INFLAMMATION 6 99.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, piroxicam had no effect on 37 degrees C-induced upregulation of any of the surface proteins, while indomethacin showed no effect on 37 degrees C-induced CD11b upregulation but suppressed CD11c and CD35 upregulation.

Negative_regulation (suppressed) of Positive_regulation (upregulation) of CD35

1) Confidence 0.18 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.13 Pain Relevance 0.13

Nonsteroidal antiinflammatory agents inhibit upregulation of CD11b, CD11c, and CD35 in neutrophils stimulated by formyl-methionine-leucine-phenylalanine.

Negative_regulation (inhibit) of Positive_regulation (upregulation) of CD35 in neutrophils associated with inflammation

2) Confidence 0.18 Published 1990 Journal Inflammation Section Title Doc Link 2138999 Disease Relevance 0.20 Pain Relevance 0.18

Both piroxicam and indomethacin inhibited FMLP-induced upregulation of CD11b, CD11c, and CD35, but neither drug affected the upregulation of these surface molecules induced by C5a or ionomycin.

Negative_regulation (inhibited) of Positive_regulation (upregulation) of CD35

3) Confidence 0.13 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.15 Pain Relevance 0.16

General Comments

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