INT204020

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 2.56
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per2) nucleus (Per2) protein binding transcription factor activity (Per2)
cytoplasm (Per2) signal transducer activity (Per2)
Anatomy Link Frequency
ependymal cell 2
inner nuclear layer 2
Per2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 903 100.00 Very High Very High Very High
GABA receptor 63 99.20 Very High Very High Very High
agonist 196 98.52 Very High Very High Very High
antagonist 197 97.64 Very High Very High Very High
Action potential 119 93.84 High High
Glutamate 91 92.40 High High
Neurotransmitter 164 89.08 High High
Dopamine 525 85.84 High High
dopamine receptor 28 85.44 High High
GABAergic 91 84.80 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 560 99.68 Very High Very High Very High
Ganglion Cysts 182 98.64 Very High Very High Very High
Breast Cancer 17 98.36 Very High Very High Very High
Endometriosis (extended) 4 95.32 Very High Very High Very High
Shock 14 78.76 Quite High
Sleep Disorders 34 50.00 Quite Low
Manic Depressive Disorder 7 50.00 Quite Low
Disease 16 38.00 Quite Low
Targeted Disruption 32 27.20 Quite Low
Dislocations 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disruption of per2 expression was reported to result in reduced transcription levels of other clock genes, whereas PER1 appears to act predominantly at the posttranscriptional level [16].
Negative_regulation (Disruption) of Gene_expression (expression) of per2
1) Confidence 0.52 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0
Circadian rhythms of PER2::LUC expression imaged in the SCN
Negative_regulation (rhythms) of Gene_expression (expression) of PER2
2) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.15 Pain Relevance 0
PMT recordings of PER2::LUC bioluminescence expression in the SCN were assessed for comparison with the MBH.
Negative_regulation (recordings) of Gene_expression (expression) of PER2
3) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.45 Pain Relevance 0
Rayleigh vector plots indicated that, unlike in the SCN, the phase of peak PER2::LUC expression in the Arc and DMH was significantly correlated with time of cull (p < 0.00001; see additional file 1: Fig.
Negative_regulation (phase) of Gene_expression (expression) of PER2 associated with aids-related complex
4) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.61 Pain Relevance 0
Intact MBH slice cultures were initially imaged on the EM-CCD camera to confirm the location of PER2::LUC expression in the Arc, ME/PT and DMH, and then placed in PMTs.
Negative_regulation (location) of Gene_expression (expression) of PER2 associated with aids-related complex
5) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.63 Pain Relevance 0
Circadian rhythmicity in PER2::LUC expression was observed in all slices and was sustained for ~1 week (mean ± SEM: 6.9 ± 1.0; Fig. 2B, Table 1).
Negative_regulation (rhythmicity) of Gene_expression (expression) of PER2
6) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0 Pain Relevance 0
All recordings revealed clear PER2::LUC expression in the DMH, primarily in the pars compacta region (DMHc), in the Arc, ME/PT and in the ependymal cell layer of the third ventricle, but surprisingly, not in the VMH.
Negative_regulation (revealed) of Gene_expression (expression) of PER2 in ependymal cell associated with aids-related complex
7) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.25 Pain Relevance 0
PER2::LUC expression was observed in the ME/PT in all MBH slices and was often clearly delineated in the PT region.
Negative_regulation (delineated) of Gene_expression (expression) of PER2
8) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0 Pain Relevance 0
However, retinal PER2::LUC rhythms persisted during blockade of GABA receptors with the GABAA receptor antagonist SR-95531 (40 ?
Negative_regulation (retinal) of Gene_expression (rhythms) of PER2 associated with antagonist and gaba receptor
9) Confidence 0.37 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.71
To test whether casein kinases are involved in the inhibitory effect of GABA on PER2::LUC levels and retinal rhythms, we applied the casein kinase inhibitor CKI-7 (50 ?
Spec (whether) Negative_regulation (inhibitory) of Gene_expression (levels) of PER2 associated with gaba
10) Confidence 0.37 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.57
However, retinal PER2::LUC rhythms persisted during blockade of GABA receptors with the GABAA receptor antagonist SR-95531 (40 ?
Negative_regulation (persisted) of Gene_expression (rhythms) of PER2 associated with antagonist and gaba receptor
11) Confidence 0.37 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.71
The wide distribution of PER2::LUC expression across the inner nuclear layer suggests that multiple inner nuclear layer cell types are sources for the rhythmic PER2::LUC signal and are likely participants in the inner retinal clock mechanism.
Negative_regulation (distribution) of Gene_expression (expression) of PER2 in inner nuclear layer
12) Confidence 0.37 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.10 Pain Relevance 0.12
Additionally, Per2 expression inhibits the expression of estrogen receptors in breast cancer cell lines [94].
Negative_regulation (inhibits) of Gene_expression (expression) of Per2 associated with breast cancer
13) Confidence 0.34 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.29 Pain Relevance 0
Retinal PER2::LUC rhythms also persisted during continuous application of the D1 receptor agonist SKF-38393 and the D2/D4 receptor agonist quinpirole hydrochloride (50 ?
Negative_regulation (persisted) of Gene_expression (rhythms) of PER2 associated with agonist
14) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.69
However, the amplitude of PER2::LUC rhythms was largely unaffected by the GABAB agonist baclofen (200 ?
Negative_regulation (amplitude) of Gene_expression (rhythms) of PER2 associated with agonist
15) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.66
Therefore, the substantial reduction in PER2::LUC expression upon GABA treatment is likely due to posttranscriptional regulation.
Negative_regulation (reduction) of Gene_expression (expression) of PER2 associated with gaba
16) Confidence 0.32 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.54
Having established the oscillatory phases of mPer2, mCry1, RevErb?
Negative_regulation (established) of Gene_expression (phases) of mPer2
17) Confidence 0.21 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.08 Pain Relevance 0

General Comments

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