INT204058

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 2006
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 7.54
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Kras) mitochondrion (Kras) plasma membrane (Kras)
GTPase activity (Kras)
Anatomy Link Frequency
hypothalamus 4
DBTRG-05MG 3
RG2 1
Kras (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Acupuncture 168 99.82 Very High Very High Very High
Potency 2 95.52 Very High Very High Very High
imagery 6 93.52 High High
Angina 6 74.00 Quite High
Central nervous system 6 31.16 Quite Low
antagonist 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
c fibre 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 186 99.84 Very High Very High Very High
Cancer 201 99.66 Very High Very High Very High
Brain Tumor 22 97.64 Very High Very High Very High
Malignant Neoplastic Disease 15 97.16 Very High Very High Very High
Urological Neuroanatomy 54 92.32 High High
Apoptosis 68 88.92 High High
Glioblastoma 76 87.40 High High
Cv General 3 Under Development 6 74.00 Quite High
Glioma 24 73.28 Quite High
Colon Cancer 1 61.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, low-frequency EA did not elicit additional effects on p21 or c-FOS expression in PCOS rat hypothalamus.


Neg (not) Regulation (elicit) of Gene_expression (expression) of p21 in hypothalamus associated with polycystic ovary syndrome and acupuncture
1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 1.16 Pain Relevance 0.23
Functional androgen response elements are present in the promoter sequences of p21 [17], and the regulation of p21 expression is AR dependent [18].
Regulation (regulation) of Gene_expression (expression) of p21
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.90 Pain Relevance 0.21
However, low-frequency EA did not elicit additional effects on p21 or c-FOS expression in PCOS rat hypothalamus.


Neg (not) Regulation (effects) of Gene_expression (expression) of p21 in hypothalamus associated with polycystic ovary syndrome and acupuncture
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 1.15 Pain Relevance 0.23
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Regulation (regulated) of Gene_expression (expression) of p21 in DBTRG-05MG
4) Confidence 0.05 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.74 Pain Relevance 0.17
The increase in p53 seen in the GLA treated tumour did not lead to altered p21 expression which could explain why pRb was not increased in this model.
Regulation (altered) of Gene_expression (expression) of p21 associated with cancer
5) Confidence 0.02 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.85 Pain Relevance 0
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Regulation (regulated) of in RG2 Gene_expression (expression) of p21 in DBTRG-05MG
6) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.74 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox