INT204062

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Anatomy Link Frequency
RG2 2
Cdk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 38 100.00 Very High Very High Very High
Death 3 59.68 Quite High
Apoptosis 30 57.84 Quite High
Brain Tumor 11 50.00 Quite Low
Malignant Neoplastic Disease 7 50.00 Quite Low
Cancer 79 23.80 Low Low
Cv General 3 Under Development 3 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein expression of cdk2, cdk4, cdk6, cyclin D1 and cyclin E in BP-treated GBM cells was also measured, and all five proteins were decreased in DBTRG-05MG and DBTRG 8401 cells; similar results for cdk2, cdk4, cdk6, cyclin D1, cyclin E and p21 were detected in RG2 cells after treatment with BP (Fig. 2b).
Negative_regulation (measured) of Gene_expression (expression) of cdk4 in RG2 associated with glioblastoma
1) Confidence 0.12 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.47 Pain Relevance 0

General Comments

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