INT204063

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Anatomy Link Frequency
RG2 2
Cdk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 6 90.60 High High
antagonist 38 50.80 Quite High
Sciatic nerve 2 25.40 Quite Low
Central nervous system 26 5.00 Very Low Very Low Very Low
Hippocampus 26 5.00 Very Low Very Low Very Low
adenocard 24 5.00 Very Low Very Low Very Low
Neurotransmitter 24 5.00 Very Low Very Low Very Low
ischemia 18 5.00 Very Low Very Low Very Low
Glutamate 18 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 76 98.20 Very High Very High Very High
Death 16 72.00 Quite High
Apoptosis 68 70.16 Quite High
Cancer 164 65.12 Quite High
Brain Tumor 22 50.00 Quite Low
Malignant Neoplastic Disease 14 50.00 Quite Low
Gliosis 2 48.48 Quite Low
Cicatrix 2 35.72 Quite Low
Neurodegenerative Disease 26 5.00 Very Low Very Low Very Low
Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relevant proteins include three D-type cyclins (D1, D2, and D3) that, in different combinations, bind to and allosterically regulate one of two cdk subunits, cdk4 and cdk6, as well as the E-type cyclins (E1 and E2), which govern the activity of a single catalytic subunit, cdk2 [176].
Gene_expression (one) of cdk4
1) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0 Pain Relevance 0
The protein expression of cdk2, cdk4, cdk6, cyclin D1 and cyclin E in BP-treated GBM cells was also measured, and all five proteins were decreased in DBTRG-05MG and DBTRG 8401 cells; similar results for cdk2, cdk4, cdk6, cyclin D1, cyclin E and p21 were detected in RG2 cells after treatment with BP (Fig. 2b).
Gene_expression (expression) of cdk4 in RG2 associated with glioblastoma
2) Confidence 0.21 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.46 Pain Relevance 0
Moreover, MAPKs are upstream regulators of cdk2 and cdk4 expression.
Gene_expression (expression) of cdk4
3) Confidence 0.19 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.07 Pain Relevance 0.12
The protein expression of cdk2, cdk4, cdk6, cyclin D1 and cyclin E in BP-treated GBM cells was also measured, and all five proteins were decreased in DBTRG-05MG and DBTRG 8401 cells; similar results for cdk2, cdk4, cdk6, cyclin D1, cyclin E and p21 were detected in RG2 cells after treatment with BP (Fig. 2b).
Gene_expression (detected) of cdk4 in RG2 associated with glioblastoma
4) Confidence 0.07 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.37 Pain Relevance 0

General Comments

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