INT204065

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 3.49
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) cell death (Cdkn1b) nucleus (Cdkn1b)
cell cycle (Cdkn1b) protein complex (Cdkn1b) response to stress (Cdkn1b)
Anatomy Link Frequency
DBTRG-05MG 3
RG2 1
Cdkn1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 2 95.52 Very High Very High Very High
imagery 6 93.52 High High
Angina 6 74.00 Quite High
Bile 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Tumor 22 97.64 Very High Very High Very High
Malignant Neoplastic Disease 14 97.16 Very High Very High Very High
Cancer 158 92.08 High High
Glioblastoma 76 87.40 High High
Apoptosis 60 85.28 High High
Cv General 3 Under Development 6 74.00 Quite High
Death 6 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Regulation (regulated) of Gene_expression (expression) of p27 in DBTRG-05MG
1) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.75 Pain Relevance 0.17
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Regulation (regulated) of in RG2 Gene_expression (expression) of p27 in DBTRG-05MG
2) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.75 Pain Relevance 0.17

General Comments

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