INT204069

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.08
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
myocytes 2
RG2 2
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 61 85.04 High High
Inflammation 7 77.44 Quite High
ischemia 32 60.24 Quite High
Central nervous system 2 40.76 Quite Low
Kinase C 21 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 142 99.92 Very High Very High Very High
Glioblastoma 38 97.26 Very High Very High Very High
Aging 38 96.44 Very High Very High Very High
Ganglion Cysts 3 95.44 Very High Very High Very High
Glaucoma 1 91.40 High High
Injury 16 88.64 High High
Parkinson's Disease 2 87.08 High High
Hepatotoxicity 24 82.88 Quite High
Stress 32 81.48 Quite High
INFLAMMATION 9 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this decrease was associated with a marked reduction in Bcl-2 rather than with an increase in Bax itself [24].
Negative_regulation (reduction) of Positive_regulation (increase) of Bax
1) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.58 Pain Relevance 0.09
However, taurine treatment inhibited As-induced up-regulation of Bad, Bax and down-regulation of Bcl-2, Bcl-xL.
Negative_regulation (inhibited) of Positive_regulation (regulation) of Bax
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.72 Pain Relevance 0
Prior treatment of natansnin (both concentrations) reduced the incidence of apoptosis by decreasing the activation of Bax and Bid.
Negative_regulation (decreasing) of Positive_regulation (activation) of Bax associated with apoptosis
3) Confidence 0.24 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.98 Pain Relevance 0.10
In addition to these losses in contractile proteins, we also observed a loss of myocyte size, a dramatic increase in the abundance of Bax, a shift in the Bax/Bcl-2 ratio and an increase in the number of myocytes undergoing apopotosis (Figures 7B, 8A and 8B).
Negative_regulation (loss) of Positive_regulation (increase) of Bax in myocytes
4) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.32 Pain Relevance 0.15
Levels of p16, p21, Bax and AIF protein in BP-treated GBM cells were therefore measured, and protein expression levels of all four proteins increased in DBTRG-05MG and DBTRG 8401 cells; similar results for p27, Bax and AIF were detected in RG2 cells after treatment with BP (Figs 2b and c).
Negative_regulation (detected) of Positive_regulation (results) of Bax in RG2 associated with glioblastoma
5) Confidence 0.11 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.47 Pain Relevance 0

General Comments

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