INT20410

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Context Info
Confidence 0.30
First Reported 1982
Last Reported 1993
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.66
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
arcuate nucleus 2
brain 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 100.00 Very High Very High Very High
Opioid 5 99.90 Very High Very High Very High
narcan 12 96.40 Very High Very High Very High
antagonist 5 95.36 Very High Very High Very High
anesthesia 1 92.80 High High
agonist 4 91.04 High High
Morphine 6 90.52 High High
Clonidine 9 84.80 Quite High
opiate 3 78.16 Quite High
Serotonin 1 77.72 Quite High
Disease Link Frequency Relevance Heat
Obesity 16 99.40 Very High Very High Very High
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Panic Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of nerve cells of the arcuate nucleus and endogenous opioid peptides in the regulation of GH and prolactin secretion has been investigated.
Regulation (role) of Regulation (regulation) of GH in arcuate nucleus associated with endogenous opioid
1) Confidence 0.30 Published 1983 Journal J. Endocrinol. Section Abstract Doc Link 6833931 Disease Relevance 0 Pain Relevance 0.34
In the present study the alpha receptors involved in GH regulation were characterized with respect to subtype.
Regulation (involved) of Regulation (regulation) of GH
2) Confidence 0.26 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6291085 Disease Relevance 0 Pain Relevance 0.32
The data indicate that alprazolam, but not diazepam, activates brain alpha 2-adrenoceptors involved in rat GH regulation.
Regulation (involved) of Regulation (regulation) of GH in brain
3) Confidence 0.26 Published 1986 Journal Life Sci. Section Abstract Doc Link 2871466 Disease Relevance 0 Pain Relevance 0.36
The GH response to both GRF doses tested was unchanged in 6-week-old obese rats as compared to their lean litter mates.
Neg (unchanged) Regulation (unchanged) of Regulation (response) of GH associated with obesity
4) Confidence 0.24 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 2139233 Disease Relevance 0.66 Pain Relevance 0.09
These results clearly indicate that opioids are involved not only in the regulation of GH and PRL release but also in the gene expression of the two hormones.
Regulation (involved) of Regulation (regulation) of GH associated with opioid
5) Confidence 0.23 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 1.25

General Comments

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