INT20411

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Context Info
Confidence 0.56
First Reported 1987
Last Reported 2004
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.62
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh, Gh1) extracellular region (Ghrh, Gh1) cytosol (Gh1)
signal transduction (Gh1) mitochondrion (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 1
median eminence 1
Ghrh (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 11 99.60 Very High Very High Very High
Somatostatin 16 99.36 Very High Very High Very High
Potency 2 94.40 High High
Enkephalin 2 93.84 High High
Intracerebroventricular 3 93.40 High High
Endogenous opioid 1 91.68 High High
Morphine 3 89.68 High High
anesthesia 4 88.80 High High
Opioid 3 84.16 Quite High
Clonidine 4 77.20 Quite High
Disease Link Frequency Relevance Heat
Obesity 16 99.00 Very High Very High Very High
Body Weight 1 26.24 Quite Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynamic of the GRF-induced GH response in genetically obese Zucker rats: influence of central and peripheral factors.
GRF Positive_regulation (induced) of GH associated with obesity
1) Confidence 0.56 Published 1990 Journal Regul. Pept. Section Title Doc Link 2139233 Disease Relevance 0.62 Pain Relevance 0.09
Reduction of somatostatin caused enhanced GH response to GRF and no increase in basal GH level with pre-treatment of antiserum against somatostatin.
GRF Neg (no) Positive_regulation (increase) of GH associated with somatostatin
2) Confidence 0.46 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.49
Moreover we have evaluated in intact male rats the effect of exogenous GH on median eminence (ME) GHRH stores and the ability of FK 33-824 to stimulate GH and prolactin (PRL) secretion and of exogenous GHRH to induce GH secretion.
GHRH Positive_regulation (stimulate) of GH in median eminence
3) Confidence 0.33 Published 1987 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2957419 Disease Relevance 0 Pain Relevance 0.53
In rats with SRIF depletion CGRP did not modify the stimulation of GH by GHRH.
GHRH Positive_regulation (stimulation) of GH associated with somatostatin and calcitonin gene-related peptide
4) Confidence 0.31 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2785661 Disease Relevance 0 Pain Relevance 1.04
Besides, KP-102 showed GH-releasing activity in conscious dogs as well, while GHRH failed to increase serum GH levels in conscious dogs.
GHRH Neg (failed) Positive_regulation (increase) of GH
5) Confidence 0.26 Published 2004 Journal Arzneimittelforschung Section Abstract Doc Link 15646370 Disease Relevance 0 Pain Relevance 0.25
These results indicate that HST calves responded to exogenous GHRF with an abrupt increase in plasma GH, but GH response to GHRF during SRIH infusion was greatly inhibited.
GHRF Positive_regulation (response) of GH in plasma
6) Confidence 0.19 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2904152 Disease Relevance 0 Pain Relevance 0.08

General Comments

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