INT204112

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 38.74
Pain Relevance 11.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GEM) plasma membrane (GEM) GTPase activity (GEM)
Anatomy Link Frequency
lymphocytes 4
joint 3
T cells 3
AsPC-1 2
tail 1
GEM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 970 99.84 Very High Very High Very High
Inflammation 335 97.24 Very High Very High Very High
dorsal root ganglion 82 96.36 Very High Very High Very High
spinal inflammation 23 94.04 High High
Arthritis 32 86.64 High High
cytokine 3 79.20 Quite High
Inflammatory response 5 69.84 Quite High
hyperexcitability 14 59.12 Quite High
Hyperalgesia 25 50.00 Quite Low
potassium channel 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1004 99.84 Very High Very High Very High
Pancreatic Cancer 192 99.84 Very High Very High Very High
Disease 554 99.80 Very High Very High Very High
Apoptosis 168 99.64 Very High Very High Very High
Syndrome 64 98.72 Very High Very High Very High
Thrombocytopenia 16 98.36 Very High Very High Very High
Infection 14 98.28 Very High Very High Very High
Death 6 98.04 Very High Very High Very High
Arthropathy 31 97.56 Very High Very High Very High
Mycobacterial Infection 31 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that an as yet unidentified adaptor molecule could associate with and stabilize cell surface expression of activating KIR in T cells that do not express DAP12.
Gene_expression (expression) of KIR in T cells
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.31 Pain Relevance 0.15
KIR genes are expressed by natural killer cells as well as memory ?
Gene_expression (expressed) of KIR in natural killer cells
2) Confidence 0.75 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.31 Pain Relevance 0.04
Notably, expression of the killer cell immunoglobulin-like inhibitory receptors (KIR) is increased.
Gene_expression (expression) of KIR
3) Confidence 0.75 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.37 Pain Relevance 0.03
Nakamura et al [67] demonstrated that the Kir7.1 channel protein is expressed in the apical membrane of the choroid plexus using immunocytochemical methods.
Gene_expression (expressed) of Kir in choroid plexus
4) Confidence 0.58 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0
KIR expression.
Gene_expression (expression) of KIR
5) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.98 Pain Relevance 0.32
disease activity; therefore, the clinical use of KIR expression
Gene_expression (expression) of KIR associated with disease
6) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.77 Pain Relevance 0.27
correlation between KIR expression and disease activity.
Gene_expression (expression) of KIR associated with disease
7) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 1.06 Pain Relevance 0.32
decrease in KIR expression, and (iii) patients with an increase in
Gene_expression (expression) of KIR
8) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.98 Pain Relevance 0.32
KIR expression may be involved in the pathogenesis of RA as well
Gene_expression (expression) of KIR associated with rheumatoid arthritis
9) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 1.53 Pain Relevance 0.48
Thus, we measured KIR expression on lymphocytes in patients with RA, and assessed the correlation between KIR expression and disease activity.
Gene_expression (expression) of KIR in lymphocytes associated with rheumatoid arthritis and disease
10) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1804296 Disease Relevance 0.89 Pain Relevance 0.31
Finally, there was no correlation between KIR expression and
Gene_expression (expression) of KIR
11) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.83 Pain Relevance 0.29
Low KIR expression on CD8+ T cells in RA might be associated with the mechanism of
Gene_expression (expression) of KIR in T cells associated with rheumatoid arthritis
12) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 1.23 Pain Relevance 0.42
further analysis of KIR expression on the cells of several
Gene_expression (expression) of KIR
13) Confidence 0.42 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.84 Pain Relevance 0.30
Thus, we measured KIR expression on lymphocytes in patients with RA, and assessed the correlation between KIR expression and disease activity.
Gene_expression (expression) of KIR in lymphocytes associated with rheumatoid arthritis and disease
14) Confidence 0.36 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1804296 Disease Relevance 0.89 Pain Relevance 0.31
suggest that unnatural KIR expression contributes to one of the
Gene_expression (expression) of KIR
15) Confidence 0.36 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.94 Pain Relevance 0.32
patients with no changes in KIR expression, (ii) patients with a
Gene_expression (expression) of KIR
16) Confidence 0.36 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.99 Pain Relevance 0.32
should be limited, while unnatural KIR expression may be involved
Gene_expression (expression) of KIR
17) Confidence 0.36 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.71 Pain Relevance 0.24
whether KIR expression correlates with disease activity in
Gene_expression (expression) of KIR associated with disease
18) Confidence 0.36 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.98 Pain Relevance 0.28
that unnatural KIR expression contributes to one of the triggers
Gene_expression (expression) of KIR
19) Confidence 0.36 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 1.14 Pain Relevance 0.37
There was no correlation between KIR expression and disease activity; therefore, the clinical use of KIR expression should be limited, while unnatural KIR expression may be involved in the pathogenesis of RA, but not a recruitment of chronic inflammation to induce joint damage.


1.

Gene_expression (expression) of KIR in joint associated with inflammation, rheumatoid arthritis and disease
20) Confidence 0.32 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1804296 Disease Relevance 0.96 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox