INT204124

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 20.79
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
blood 2
saliva 1
body 1
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 30 98.48 Very High Very High Very High
rheumatoid arthritis 9 97.64 Very High Very High Very High
Inflammation 260 97.40 Very High Very High Very High
anesthesia 6 87.92 High High
epidural 1 87.48 High High
cytokine 35 82.80 Quite High
Angina 17 82.20 Quite High
Inflammatory response 18 77.68 Quite High
diclofenac 53 75.60 Quite High
addiction 12 71.52 Quite High
Disease Link Frequency Relevance Heat
Cardiovascular Disease 72 99.80 Very High Very High Very High
Diabetes Mellitus 50 99.80 Very High Very High Very High
Thyroiditis 73 99.44 Very High Very High Very High
Pathologic Dilatation 250 98.96 Very High Very High Very High
Thyroid Disease 9 98.88 Very High Very High Very High
Obesity 207 98.56 Very High Very High Very High
Frailty 30 98.48 Very High Very High Very High
Coronary Artery Disease 164 97.68 Very High Very High Very High
Rheumatoid Arthritis 9 97.64 Very High Very High Very High
INFLAMMATION 305 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BMI = body mass index; CRP = C-reactive protein; CV = coefficient of variation; hsCRP = high sensitivity CRP; IL = interleukin; ln = natural log; OA = osteoarthritis; RA = rheumatoid arthritis; SD = standard deviation; TNF?
Transcription (sensitivity) of CRP in body associated with obesity, rheumatoid arthritis and osteoarthritis
1) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 1.45 Pain Relevance 0.53
High-sensitive CRP (hs-CRP) was shown to be an
Transcription (sensitive) of CRP
2) Confidence 0.67 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 1.82 Pain Relevance 0.20
decreases in hs-CRP were observed in patients with higher baseline
Transcription (observed) of hs-CRP
3) Confidence 0.59 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 2.09 Pain Relevance 0.03
group no correlation was observed between hs-CRP and DM supporting
Neg (no) Transcription (observed) of hs-CRP associated with diabetes mellitus
4) Confidence 0.59 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 2.05 Pain Relevance 0.07
High-sensitive CRP (hs-CRP) was shown to be an
Transcription (sensitive) of hs-CRP
5) Confidence 0.59 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 1.82 Pain Relevance 0.20
A positive correlation was observed between hs-CRP and
Transcription (observed) of hs-CRP
6) Confidence 0.59 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 2.08 Pain Relevance 0
But data on CRP levels in saliva of HT and SAT patients are lacking in literature.
Transcription (levels) of CRP in saliva associated with thyroiditis
7) Confidence 0.53 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.47 Pain Relevance 0.25
Among both women and men, minor alleles were significantly associated with higher CRP levels for SNPs 1919A>T and 4741G>C, but associated with lower CRP levels for SNPs 2667G>C and 3872C>T.
Transcription (levels) of CRP
8) Confidence 0.53 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2148071 Disease Relevance 0.85 Pain Relevance 0.03
Furthermore, the transcription factor STAT3, which can activate CRP transcription [12], has a central position in the network.
Transcription (transcription) of CRP
9) Confidence 0.51 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.62 Pain Relevance 0.26
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Transcription (levels) of CRP
10) Confidence 0.48 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.49
Japanese American men in Honolulu were examined 25 years after a blood sample was taken to measure C-reactive protein (CRP), using very sensitive assays [49].
Transcription (measure) of CRP in blood
11) Confidence 0.29 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.98 Pain Relevance 0.21
Japanese American men in Honolulu were examined 25 years after a blood sample was taken to measure C-reactive protein (CRP), using very sensitive assays [49].
Transcription (measure) of C-reactive protein in blood
12) Confidence 0.29 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.98 Pain Relevance 0.21
A strong correlation was described between hs-CRP and CVD events, when hs-CRP exceeded 3 mg/l [40].
Transcription (described) of hs-CRP associated with cardiovascular disease
13) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.02 Pain Relevance 0.15
Identifying the “reactive” versus “causative” transcripts
Transcription (transcripts) of reactive
14) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2880558 Disease Relevance 0.20 Pain Relevance 0.06

General Comments

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