INT20418

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 4.40
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
MDA-MB-231 2
T-cell 2
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 100.00 Very High Very High Very High
Paracetamol 11 100.00 Very High Very High Very High
cytokine 7 100.00 Very High Very High Very High
opiate 1 98.36 Very High Very High Very High
narcan 3 92.92 High High
Arthritis 1 89.36 High High
Angina 1 81.24 Quite High
potassium channel 1 75.00 Quite High
cINOD 5 73.96 Quite High
antagonist 5 36.40 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Adhesions 6 100.00 Very High Very High Very High
Necrosis 4 99.12 Very High Very High Very High
Cancer 27 98.94 Very High Very High Very High
Apoptosis 68 98.72 Very High Very High Very High
Chromosome Aberrations 2 97.48 Very High Very High Very High
Breast Cancer 3 96.12 Very High Very High Very High
Endometriosis (extended) 1 95.08 Very High Very High Very High
Congenital Anomalies 2 91.92 High High
Primary Effusion Lymphoma 4 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that opiate receptors and K+ channels of Jurkat cells are functionally coupled in a way that modulates intracellular calcium release and c-myc expression - two key processes in T-cell mitogenesis.
Regulation (modulates) of Gene_expression (expression) of c-myc in T-cell associated with opiate
1) Confidence 0.60 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 2139666 Disease Relevance 0 Pain Relevance 0.22
factor responsible for c-myc expression, was completely inhibited [147].
Regulation (responsible) of Gene_expression (expression) of c-myc
2) Confidence 0.60 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.89 Pain Relevance 0
Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21(CIP1/WAF1), and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells.
Regulation (effects) of Gene_expression (expression) of c-myc in MDA-MB-231 associated with paracetamol, endometriosis (extended) and breast cancer
3) Confidence 0.44 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11896290 Disease Relevance 0.36 Pain Relevance 0.54
We did not detect C-MYC gene rearrangement or BCL-2 expression.
Neg (not) Regulation (detect) of Gene_expression (expression) of C-MYC
4) Confidence 0.44 Published 2005 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 15588855 Disease Relevance 1.17 Pain Relevance 0.08
A triple function of PLA2-derived lipid mediators has been suggested: causing immediate inflammatory signs, involvement in secondary processes, e.g., superoxide free radical (O2) generation, apoptosis, or tumour necrosis factor-alpha (TNF-alpha)-cytotoxicity, and controlling the expression and activation of pivotal proteins implicated in inflammation and cell development, e.g., cytokines, adhesion proteins, proteinases, NF-kappaB, fos/jun/AP-1, c-Myc, or p21ras.
Regulation (controlling) of Gene_expression (expression) of c-Myc associated with necrosis, inflammation, cancer, apoptosis, adhesions and cytokine
5) Confidence 0.44 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989628 Disease Relevance 0.84 Pain Relevance 0.31
The mRNA and protein levels of p53, p21waf1/cip1, and c-myc were determined by Northern and Western blotting.
Spec (determined) Regulation (determined) of Spec (determined) Gene_expression (levels) of c-myc
6) Confidence 0.26 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.98 Pain Relevance 0.15
We have recently generated immortalized human MSC lines by the conditional expression of v-myc under control of a regulatable tetracycline (Tet) promoter.
Regulation (control) of Gene_expression (expression) of v-myc
7) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.17 Pain Relevance 0

General Comments

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