INT204181

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 22
Total Number 42
Disease Relevance 30.66
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD209) cell adhesion (CD209) plasma membrane (CD209)
intracellular (CD209) cytoplasm (CD209)
Anatomy Link Frequency
monocytes 5
macrophages 3
dendritic cells 3
Raji 2
T cells 2
CD209 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 180 98.92 Very High Very High Very High
alcohol 21 98.60 Very High Very High Very High
cytokine 331 97.52 Very High Very High Very High
Inflammation 112 86.84 High High
cva 63 84.52 Quite High
Pain 6 65.92 Quite High
Inflammatory mediators 18 56.88 Quite High
imagery 5 51.40 Quite High
dexamethasone 4 48.88 Quite Low
abdominal pain 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 2145 99.92 Very High Very High Very High
Systemic Lupus Erythematosus 336 99.64 Very High Very High Very High
Dengue 1317 99.52 Very High Very High Very High
Disease 171 99.48 Very High Very High Very High
Dengue Hemorrhagic Fever 1008 97.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 386 97.52 Very High Very High Very High
Cold Sores 76 96.82 Very High Very High Very High
Adhesions 82 96.56 Very High Very High Very High
Congenital Anomalies 25 94.72 High High
Communicable Diseases 42 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DC-SIGN, also called CD209, expresses on dendritic cells (DCs) that bind to ICAM-3, which is expressed on T cells to facilitate the initial interaction between DCs and T cells.
Gene_expression (expresses) of DC-SIGN in DCs
1) Confidence 0.64 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 1.54 Pain Relevance 0
As an in vitro study of promoter activity might not reflect an actual functional association, we aimed to test whether the rs4804803 SNP in the promoter region of CD209 was associated with the susceptibility to DF and/or DHF in Taiwanese, and whether monocyte-derived DCs from humans with various genotypes of rs4804803 would reveal differences in DC-SIGN membrane expression and implicate the viral replication and immune reactions after DEN infection.


Gene_expression (expression) of DC-SIGN in monocyte associated with dengue, dengue hemorrhagic fever and infection
2) Confidence 0.64 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.85 Pain Relevance 0
This suggests that rs4804803 SNP was involved in the DC-SIGN expression associated with augmented immune response, such as the increase in the production of IP-10 that repressed the replication of DEN.
Gene_expression (expression) of DC-SIGN
3) Confidence 0.64 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.43 Pain Relevance 0.03
Functional studies have determined that MDDCs from individuals with AG genotype have a significantly higher cell surface DC-SIGN expression than from those with AA genotype.
Gene_expression (expression) of DC-SIGN
4) Confidence 0.64 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.64 Pain Relevance 0
This SNP with AG genotype affects the cell surface DC-SIGN expression related to immune augmentation and less viral replication.


Gene_expression (expression) of DC-SIGN
5) Confidence 0.64 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 1.60 Pain Relevance 0
Genotyping for the CD209 variant (?
Gene_expression (variant) of CD209
6) Confidence 0.64 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.97 Pain Relevance 0.08
Genotyping of CD209 rs4804803 SNP
Gene_expression (rs4804803) of CD209
7) Confidence 0.64 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.41 Pain Relevance 0.08
HMB-PP-activated monocytes expressed CD83, CD206 (mannose receptor) and CD209 (DC-SIGN) (Fig. 4C), while CD205 (DEC-205) and CD207 (langerin) were absent (Table S1).
Gene_expression (expressed) of DC-SIGN in monocytes
8) Confidence 0.58 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0
We examined DC-SIGN (CD209) expression in both mRNA level of MDDCs and protein level on their cell surface from healthy subjects with AA or AG genotype by quantitative RT-PCR and flow cytometry, respectively.
Spec (examined) Gene_expression (expression) of CD209
9) Confidence 0.57 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.29 Pain Relevance 0
Moreover, MDDCs from individuals with AG genotype with a higher cell surface DC-SIGN expression had a significantly higher TNF?
Gene_expression (expression) of DC-SIGN
10) Confidence 0.56 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 1.52 Pain Relevance 0
To measure the CD209 cell surface expression, MDDCs were stained with FITC-conjugated mAbs specific for DC-SIGN (R&D Systems, Minneapolis, MN, USA).
Gene_expression (expression) of CD209
11) Confidence 0.56 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.12 Pain Relevance 0.10
To investigate whether higher cell surface DC-SIGN expression was correlated with immune response, we investigated kinetic cytokine/chemokine production by MDDCs from individuals with AA or AG genotype of rs4804803.
Spec (whether) Gene_expression (expression) of DC-SIGN associated with chemokine and cytokine
12) Confidence 0.56 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.67 Pain Relevance 0.19
The forward primer, reverse primer sequence for detecting CD209 and B2MG were 5?
Gene_expression (detecting) of CD209
13) Confidence 0.50 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.34 Pain Relevance 0.03
These results differ from a previous study by Loach et al. who demonstrated that the DC-SIGN expression levels on Raji cells after transfection of various DC-SIGN cDNA constructs were significantly correlated to the infection rate of DEN-1 [35].
Gene_expression (expression) of DC-SIGN in Raji associated with infection
14) Confidence 0.50 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.19 Pain Relevance 0.07
Results from these studies suggest that the correlation of viral replication to higher or lower DC-SIGN expression depends on genetic factors in the host, cell type, and dynamic changes in the receptor following DEN infection.
Gene_expression (expression) of DC-SIGN associated with infection
15) Confidence 0.50 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.32 Pain Relevance 0.04
We examined DC-SIGN (CD209) expression in both mRNA level of MDDCs and protein level on their cell surface from healthy subjects with AA or AG genotype by quantitative RT-PCR and flow cytometry, respectively.
Spec (examined) Gene_expression (expression) of DC-SIGN
16) Confidence 0.50 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.29 Pain Relevance 0
In functional studies of rs4804803 SNP, we determined that MDDCs with AG genotype had a higher DC-SIGN expression correlated to augmented immune responses with higher TNF?
Gene_expression (expression) of DC-SIGN
17) Confidence 0.50 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.29 Pain Relevance 0.04
These results differ from a previous study by Loach et al. who demonstrated that the DC-SIGN expression levels on Raji cells after transfection of various DC-SIGN cDNA constructs were significantly correlated to the infection rate of DEN-1 [35].
Gene_expression (expression) of DC-SIGN in Raji associated with infection
18) Confidence 0.50 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.19 Pain Relevance 0.07
In our study, it was found that MDDCs from subjects with rs4804803 AG genotype had higher surface DC-SIGN expression with higher production of chemokines such as IP-10, which could limit DEN-2 replication (Fig. 4A); however, the higher surface DC-SIGN expression in subjects with AG genotype decreased remarkably 24 h post-infection (Fig. 2A).
Gene_expression (expression) of DC-SIGN associated with chemokine and infection
19) Confidence 0.50 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.66 Pain Relevance 0.08
In our study, it was found that MDDCs from subjects with rs4804803 AG genotype had higher surface DC-SIGN expression with higher production of chemokines such as IP-10, which could limit DEN-2 replication (Fig. 4A); however, the higher surface DC-SIGN expression in subjects with AG genotype decreased remarkably 24 h post-infection (Fig. 2A).
Gene_expression (expression) of DC-SIGN associated with chemokine and infection
20) Confidence 0.50 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.85 Pain Relevance 0.08

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