INT20419

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 9.70
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
neuronal 2
Hepa 1-6 2
smooth muscle cells 2
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 255 99.90 Very High Very High Very High
narcan 3 96.56 Very High Very High Very High
Analgesic 5 96.44 Very High Very High Very High
agonist 64 95.36 Very High Very High Very High
Action potential 1 94.92 High High
antagonist 33 93.08 High High
cINOD 18 92.80 High High
COX2 6 89.36 High High
dorsal root ganglion 4 89.00 High High
opiate 1 88.80 High High
Disease Link Frequency Relevance Heat
Apoptosis 343 99.78 Very High Very High Very High
Neuroblastoma 7 98.76 Very High Very High Very High
Colon Cancer 96 97.68 Very High Very High Very High
Death 96 96.80 Very High Very High Very High
Leukemia 116 95.92 Very High Very High Very High
Hyperplasia 10 95.92 Very High Very High Very High
Hepatotoxicity 18 94.44 High High
Malignant Neoplastic Disease 51 93.76 High High
Thyroid Neoplasm 16 92.48 High High
Toxicity 13 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Longer exposure (1-2 h) to beta-endorphin retarded intracellular calcium release, and suppressed c-myc expression.
Negative_regulation (suppressed) of Gene_expression (expression) of c-myc
1) Confidence 0.57 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 2139666 Disease Relevance 0 Pain Relevance 0.22
Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity.
Negative_regulation (inhibition) of Gene_expression (expression) of c-myc in Hepa 1-6 associated with paracetamol
2) Confidence 0.57 Published 1999 Journal Toxicol. Sci. Section Title Doc Link 10353317 Disease Relevance 0.28 Pain Relevance 1.02
As a result, ornithine decarboxylase activity and c-myc protein expression were decreased.
Negative_regulation (decreased) of Gene_expression (expression) of c-myc
3) Confidence 0.57 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737227 Disease Relevance 0.08 Pain Relevance 0
The common feature consisted of the inhibition of c-myc expression, whereas the
Negative_regulation (inhibition) of Gene_expression (expression) of c-myc
4) Confidence 0.57 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.46 Pain Relevance 0
proapoptotic proteins, the expression levels of the proto-oncogene product c-myc were drastically reduced after 24
Negative_regulation (reduced) of Gene_expression (expression) of c-myc
5) Confidence 0.57 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.82 Pain Relevance 0
decrease c-myc expression in vascular smooth muscle cells [135].
Negative_regulation (decrease) of Gene_expression (expression) of c-myc in smooth muscle cells
6) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.41 Pain Relevance 0.11
downregulate c-Myc expression [12].
Negative_regulation (downregulate) of Gene_expression (expression) of c-Myc
7) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.28 Pain Relevance 0.12
arrest and apoptosis, but also downregulated the expression of c-myc mRNA and protein [187].
Negative_regulation (downregulated) of Gene_expression (expression) of c-myc associated with apoptosis
8) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.20 Pain Relevance 0.03
Reduced levels of c-Myc and phosphorylated c-Raf protein suggest the disruption of Ras-dependent signaling by HPGGT.
Negative_regulation (Reduced) of Gene_expression (levels) of c-Myc
9) Confidence 0.42 Published 2007 Journal Gastroenterology Section Body Doc Link 17484877 Disease Relevance 0 Pain Relevance 0
Moreover, depletion of PLD1 or 2 blocked expression of Wnt3a-induced target genes, including c-Myc, Cyclin D1, NOS2, and vimentin (Figure 5B).
Negative_regulation (blocked) of Gene_expression (expression) of c-Myc
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.06 Pain Relevance 0
The down-regulation of c-Myc may be an important function of Ifit-3 as previous studies have demonstrated that c-Myc expression can impair the IFN response and in particular, suppress the NF-?
Negative_regulation (suppress) of Gene_expression (expression) of c-Myc
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.06 Pain Relevance 0.66
The down-regulation of c-Myc may be an important function of Ifit-3 as previous studies have demonstrated that c-Myc expression can impair the IFN response and in particular, suppress the NF-?
Negative_regulation (impair) of Gene_expression (expression) of c-Myc
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.06 Pain Relevance 0.65
Statistical analysis revealed significant differences between the expression levels of c-myc, VEGFa, TGF-?
Negative_regulation (levels) of Gene_expression (expression) of c-myc
13) Confidence 0.41 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.30 Pain Relevance 0.13
In these in vitro studies, enhanced antiproliferative and apop-totic effects of rituximab and radiation were achieved through inhibition of c-myc and Bcl-xL expression.
Negative_regulation (inhibition) of Gene_expression (expression) of c-myc
14) Confidence 0.41 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 0.34 Pain Relevance 0
Increased transcriptional initiation of c-myc induced by the short-chain fatty acid, butyrate, consistent with elevated beta-catenin/TCF activity, was efficiently abrogated by a block to transcriptional elongation, resulting in decreased c-myc expression. 1alpha,25-Dihydroxyvitamin D(3) also induced transcriptional blockage.
Negative_regulation (decreased) of Gene_expression (expression) of c-myc
15) Confidence 0.41 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.40 Pain Relevance 0.09
Moreover, depletion of PLD1 or 2 blocked expression of Wnt3a-induced target genes, including c-Myc, Cyclin D1, NOS2, and vimentin (Figure 5B).
Negative_regulation (depletion) of Gene_expression (expression) of c-Myc
16) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.06 Pain Relevance 0
After differentiation of clone HD10.6 for 7 d in the presence of tetracycline, v-myc expression was suppressed, and >50% of the cells exhibited typical neuronal morphology, stained positively for neuronal cytoskeletal markers, and fired action potentials in response to current injection.
Negative_regulation (suppressed) of Gene_expression (expression) of v-myc in neuronal associated with action potential
17) Confidence 0.35 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10377351 Disease Relevance 0.33 Pain Relevance 0.23
(suppressing its function), with the promoter of c-MYC (suppressing expression of this protooncogene), and with promoters of other genes.
Negative_regulation (suppressing) of Gene_expression (expression) of c-MYC
18) Confidence 0.30 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.14 Pain Relevance 0
After 1 h exposure to L. plantarum WCFS1, four major transcriptional regulators were all found to be downregulated: the oncogene product MYC (c-Myc), FOS (c-Fos), JUN (c-Jun) and the p65 subunit of the NF-?
Negative_regulation (downregulated) of Gene_expression (subunit) of MYC
19) Confidence 0.16 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.78 Pain Relevance 0.03
After 1 h exposure to L. plantarum WCFS1, four major transcriptional regulators were all found to be downregulated: the oncogene product MYC (c-Myc), FOS (c-Fos), JUN (c-Jun) and the p65 subunit of the NF-?
Negative_regulation (downregulated) of Gene_expression (product) of MYC
20) Confidence 0.16 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.65 Pain Relevance 0

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