INT2042

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Context Info
Confidence 0.55
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 1.54
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
spike 1
synapses 1
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 60 100.00 Very High Very High Very High
depression 57 99.18 Very High Very High Very High
long-term potentiation 97 99.02 Very High Very High Very High
dexamethasone 128 98.88 Very High Very High Very High
tetrodotoxin 13 98.84 Very High Very High Very High
Immobilon 2 98.74 Very High Very High Very High
methadone 1 98.48 Very High Very High Very High
Glutamate 14 94.20 High High
Opioid 5 93.84 High High
agonist 22 93.36 High High
Disease Link Frequency Relevance Heat
Depression 57 99.18 Very High Very High Very High
Targeted Disruption 37 99.16 Very High Very High Very High
Coronary Heart Disease 7 94.56 High High
Myocardial Infarction 7 93.12 High High
Cognitive Disorder 45 84.40 Quite High
Nociception 10 75.00 Quite High
Reprotox - General 2 30 55.12 Quite High
Pulmonary Disease 3 54.44 Quite High
Pressure And Volume Under Development 21 51.84 Quite High
Neuroblastoma 2 48.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the Ca2+-dependent protein phosphorylation could be reversed by the addition of sufficient EGTA to chelate all free extracellular Ca2+.
Phosphorylation (phosphorylation) of Ca2
1) Confidence 0.55 Published 1977 Journal J. Biol. Chem. Section Abstract Doc Link 323254 Disease Relevance 0 Pain Relevance 0.12
The absence of any endogenous protein phosphorylation in osmotically shocked synaptosome preparations incubated with 32Pi, and the inability of added [gamma-32P]ATP to serve as a substrate for veratridine-stimulated protein phosphorylation in intact preparations, indicated that the Ca2+-dependent protein phosphorylation occurred within intact subcellular organelles.
Phosphorylation (phosphorylation) of Ca2
2) Confidence 0.55 Published 1977 Journal J. Biol. Chem. Section Abstract Doc Link 323254 Disease Relevance 0 Pain Relevance 0.15
These results suggest that 4-AP (indirectly) stimulates both Ca2+ influx and B-50 phosphorylation through voltage-dependent channels by a mechanism dependent on Na+ channel activity.
Phosphorylation (phosphorylation) of Ca2
3) Confidence 0.54 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1851203 Disease Relevance 0 Pain Relevance 0.17
Hence, we were interested in the relationship between changes induced by 4-AP in the intracellular free Ca2+ concentration ([Ca2+]i) and B-50 phosphorylation in synaptosomes. 4-AP (100 microM) elevates the [Ca2+]i (as determined with fura-2) to approximately the same extent as depolarization with 30 mM K+ (from an initial resting level of 240 nM to approximately 480 nM after treatment).
Phosphorylation (phosphorylation) of Ca2
4) Confidence 0.54 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1851203 Disease Relevance 0 Pain Relevance 0.08
Hence, we were interested in the relationship between changes induced by 4-AP in the intracellular free Ca2+ concentration ([Ca2+]i) and B-50 phosphorylation in synaptosomes. 4-AP (100 microM) elevates the [Ca2+]i (as determined with fura-2) to approximately the same extent as depolarization with 30 mM K+ (from an initial resting level of 240 nM to approximately 480 nM after treatment).
Phosphorylation (phosphorylation) of Ca2
5) Confidence 0.54 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1851203 Disease Relevance 0 Pain Relevance 0.08
The addition of methadone or etorphine to the protein kinase in vitro however, was able to block the Ca2+-calmodulin stimulation of phosphorylation in both synaptic membranes and intact synaptosomes.
Phosphorylation (phosphorylation) of Ca2 associated with methadone and immobilon
6) Confidence 0.52 Published 1982 Journal Neurochem. Res. Section Abstract Doc Link 7177312 Disease Relevance 0 Pain Relevance 0.48
Postsynaptic autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) at Thr286/287 is crucial for the induction of long-term potentiation at many glutamatergic synapses, and has also been implicated in the persistence of synaptic potentiation.
Phosphorylation (autophosphorylation) of Ca2 in synapses associated with long-term potentiation
7) Confidence 0.50 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15932602 Disease Relevance 0.13 Pain Relevance 0.05
The PTZ-stimulatory effects of both synapsin I phosphorylation and synaptosomal accumulation of Ca2+ were inhibited markedly by tetrodotoxin as well as by cobalt chloride and lanthanum chloride.
Phosphorylation (phosphorylation) of Ca2 associated with tetrodotoxin
8) Confidence 0.49 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3107572 Disease Relevance 0 Pain Relevance 0.26
Therefore our results indicate the presence of a strong interaction between the effects of phosphorylation of cTnI and MLC-2 on Ca2+-sensitivity.
Phosphorylation (phosphorylation) of Ca2
9) Confidence 0.34 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.07 Pain Relevance 0
Since cMyBP-C and cTnI phosphorylation are strongly associated (Fig. 6D), it is not possible from these experiments to distinguish directly between effects of cMyBP-C and cTnI phosphorylation on Ca2+-sensitivity of force development.
Phosphorylation (phosphorylation) of Ca2
10) Confidence 0.29 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.10 Pain Relevance 0
On the other hand, the finding that the phosphorylation level of MLC-2 was not increased may be attributed by substrate specificity of the (Ca2+-dependent) kinases and phosphatases involved.


Phosphorylation (phosphorylation) of Ca2
11) Confidence 0.29 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
If this would be the case, minor differences in phosphorylation at low cAMP levels may have a considerably larger impact on Ca2+-sensitivity than at moderate or high levels.
Phosphorylation (phosphorylation) of Ca2
12) Confidence 0.29 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.16 Pain Relevance 0.07
These alterations in phosphorylation had a large impact on Ca2+-sensitivity but not on maximum force and ktr.
Phosphorylation (phosphorylation) of Ca2
13) Confidence 0.29 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.05
A number of studies in transgenic animals, however, indicated that cMyBP-C phosphorylation has considerable impact on cardiac contractility, but not directly on Ca2+-sensitivity of isometric force [7, 16, 17].
Phosphorylation (phosphorylation) of Ca2 associated with targeted disruption
14) Confidence 0.29 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.10 Pain Relevance 0
The effects of DEX on LTP and LTD were correlated with an increase in the autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at threonine-286 and a decrease in the protein phosphatase 1 expression.
Phosphorylation (autophosphorylation) of Ca2 associated with depression, long-term potentiation and dexamethasone
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943478 Disease Relevance 0.58 Pain Relevance 0.72
Effects of phosphorylation on Ca2+-sensitivity
Phosphorylation (phosphorylation) of Ca2
16) Confidence 0.23 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.19 Pain Relevance 0.03
Serine-1412 phosphorylation was NMDA receptor-dependent and led to a rapid enhancement of NOS activity (by how much remains unclear), with dephosphorylation being dependent on AMPA receptors and L-type Ca2+channels.
Phosphorylation (phosphorylation) of Ca2 associated with nmda receptor
17) Confidence 0.08 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.21
Specifically, stimulation of Ca2+-activated K+ channels by cGMP-dependent phosphorylation enhanced presynaptic spiking by increasing the spike afterhyperpolarization, allowing more Na+ channels to recover from inactivation which, by facilitating spike conduction, increased Ca2+influx in response to trains of stimuli (Klyachko et al., 2001).
Phosphorylation (phosphorylation) of Ca2 in spike
18) Confidence 0.08 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.16
Most PDEs have a regulatory domain at the N-term that varies among the families and provides the sites for dimerization, phosphorylation and modulatory bonds such as Ca2+-CaM and cGMP.
Phosphorylation (phosphorylation) of Ca2
19) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0 Pain Relevance 0.03
For example many effects of Ca2+ on cAMP and cGMP are mediated by the activation of the Ca2+-Calmodulin (Ca2+-CaM) dependent phosphorylation of PDEs (Sonnenburg et al 1995).
Phosphorylation (phosphorylation) of Ca2
20) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.11 Pain Relevance 0.09

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