INT20420

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 99
Total Number 103
Disease Relevance 49.32
Pain Relevance 14.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
HEK 5
fibroblasts 3
colon 3
MDA-MB-231 2
U-2 OS 2
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 239 100.00 Very High Very High Very High
cytokine 88 100.00 Very High Very High Very High
B1 receptor 30 100.00 Very High Very High Very High
cINOD 90 99.92 Very High Very High Very High
Paracetamol 312 99.78 Very High Very High Very High
Morphine 9 99.76 Very High Very High Very High
potassium channel 3 99.72 Very High Very High Very High
bradykinin 4 99.58 Very High Very High Very High
midbrain 49 99.32 Very High Very High Very High
narcan 51 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 300 100.00 Very High Very High Very High
Adhesions 52 100.00 Very High Very High Very High
Lymphatic System Cancer 293 99.98 Very High Very High Very High
Thyroid Neoplasm 206 99.88 Very High Very High Very High
Colon Cancer 360 99.84 Very High Very High Very High
Epstein-barr Virus 114 99.84 Very High Very High Very High
Diabetic Foot Ulcer 1 99.64 Very High Very High Very High
Cancer 1521 99.48 Very High Very High Very High
Apoptosis 833 99.42 Very High Very High Very High
Breast Cancer 309 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
proapoptotic proteins, the expression levels of the proto-oncogene product c-myc were drastically reduced after 24
Gene_expression (expression) of c-myc
1) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.77 Pain Relevance 0
In this study we assessed the activation status of five oncogenic signaling pathways in 157 ovarian tumor samples based on the activation observed in a mammalian cell line following tranfection of adenovirus expressing human c-Myc, activated H-Ras, human c-Src, human E2F3, or ?
Gene_expression (tranfection) of c-Myc associated with ovarian cancer
2) Confidence 0.75 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.47 Pain Relevance 0
Compound 11 does not importantly modify the expression of myc-B1R over 24 h in HEK 293 cells (no detectable action as "pharmacological chaperone").
Gene_expression (expression) of myc in HEK associated with b1 receptor
3) Confidence 0.75 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277582 Disease Relevance 0 Pain Relevance 0.60
In contrast, the nonsteroidal anti-inflammatory drug, sulindac, increased c-myc expression, an effect attributable at least in part to its failure to induce transcriptional blockage.
Gene_expression (expression) of c-myc associated with inflammation and cinod
4) Confidence 0.75 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.38 Pain Relevance 0.10
The epidermis of the non-healing edge of the pressure ulcers, as well as that of venous and diabetic foot ulcers, shows increased expression of c-myc and activation of nuclear ?
Gene_expression (expression) of c-myc in edge associated with diabetic foot ulcer and decubitus ulcers
5) Confidence 0.75 Published 2009 Journal World J Surg Section Body Doc Link PMC2691928 Disease Relevance 1.53 Pain Relevance 0.10
In these in vitro studies, enhanced antiproliferative and apop-totic effects of rituximab and radiation were achieved through inhibition of c-myc and Bcl-xL expression.
Gene_expression (expression) of c-myc
6) Confidence 0.75 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 0.34 Pain Relevance 0
Statistical analysis revealed significant differences between the expression levels of c-myc, VEGFa, TGF-?
Gene_expression (expression) of c-myc
7) Confidence 0.75 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.30 Pain Relevance 0.13
Furthermore, in adenomas, a down-regulation of APC after treatment and a tight correlation of the expressions of the two Wnt targets, c-myc and cyclin D1, in both stages of treatment were observed.
Gene_expression (expressions) of c-myc
8) Confidence 0.75 Published 2002 Journal Anticancer Res. Section Body Doc Link 12174906 Disease Relevance 0.08 Pain Relevance 0
PATIENTS AND METHODS: The expressions of the Wnt members and targets APC, c-myc, cyclin D1 and COX-2, as measured by real-time quantitative RT-PCR, have been evaluated in fresh samples of normal colorectal mucosa and matched adenoma tissue of six unrelated FAP patients before and after treatment with meloxicam.
Gene_expression (expressions) of c-myc
9) Confidence 0.75 Published 2002 Journal Anticancer Res. Section Body Doc Link 12174906 Disease Relevance 0.10 Pain Relevance 0
We did not detect C-MYC gene rearrangement or BCL-2 expression.
Gene_expression (expression) of C-MYC
10) Confidence 0.75 Published 2005 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 15588855 Disease Relevance 1.17 Pain Relevance 0.08
Furthermore, the extent of energy transfer following co-expression of c-Myc–hCXCR2 and FLAG–hDOP was virtually the same as when c-Myc–hDOP and FLAG–hDOP were co-expressed to generate tr-FRET competent, cell-surface hDOP homodimers (Figure 2A).
Gene_expression (expression) of c-Myc
11) Confidence 0.75 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0
The common feature consisted of the inhibition of c-myc expression, whereas the
Gene_expression (expression) of c-myc
12) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.46 Pain Relevance 0
This did not occur when HEK-293 cell populations individually expressing either c-Myc–hCXCR2 or FLAG–hDOP were combined prior to addition of the combination of Eu3+-labelled and APC-labelled antibodies (Figure 2A).
Gene_expression (expressing) of c-Myc
13) Confidence 0.75 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0
factor responsible for c-myc expression, was completely inhibited [147].
Gene_expression (expression) of c-myc
14) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.89 Pain Relevance 0
These nine cases all expressed c-myc, bcl-2, and had high Ki-67 scores [14].
Gene_expression (expressed) of myc
15) Confidence 0.75 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.55 Pain Relevance 0
ER-positive tumours fell into 2 subdivisions; subsets A and B both expressing luminal cytokeratins 8/18 but showing differential expression of HER2, c-Myc and PGR.
Gene_expression (expression) of c-Myc associated with cancer
16) Confidence 0.75 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.12 Pain Relevance 0
Expression of c-Myc–hDOP resulted in the presence of a c-Myc-reactive polypeptide with a molecular mass of 60 kDa (Figure 1).
Gene_expression (Expression) of c-Myc
17) Confidence 0.75 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.15
Expression of the ER and PgR genes, c-myb, c-erb2, c-myc, c-fos, the epidermal growth factor receptor (EGFR) gene, and pS2 (a small secreted protein isolated from MCF7 cells after induction by 17?
Gene_expression (Expression) of c-myc in MCF7
18) Confidence 0.75 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.85 Pain Relevance 0
Specifically, the expression of early cell cycle genes such as c-fos and c-myc is also stimulated by integrin-mediated cell adhesion, and gene expression driven by the fos promoter shows strong synergistic activation by integrin-mediated adhesion [27,28].
Gene_expression (expression) of c-myc associated with adhesions
19) Confidence 0.75 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 1.07 Pain Relevance 0.17
Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21(CIP1/WAF1), and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells.
Gene_expression (expression) of c-myc in MDA-MB-231 associated with paracetamol, endometriosis (extended) and breast cancer
20) Confidence 0.75 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11896290 Disease Relevance 0.36 Pain Relevance 0.54

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