INT20421

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 10.43
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
epithelial cells 2
thyroid 1
liver 1
uterine 1
intestine 1
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 21 99.92 Very High Very High Very High
Paracetamol 12 99.84 Very High Very High Very High
agonist 42 91.08 High High
palliative 3 90.88 High High
narcan 9 89.04 High High
psoriasis 1 87.48 High High
Enkephalin 10 87.40 High High
opiate 3 76.96 Quite High
potassium channel 1 75.00 Quite High
MU agonist 16 71.24 Quite High
Disease Link Frequency Relevance Heat
Alagille Syndrome 9 99.56 Very High Very High Very High
Apoptosis 78 99.36 Very High Very High Very High
INFLAMMATION 66 99.20 Very High Very High Very High
Thyroid Neoplasm 88 98.70 Very High Very High Very High
Carcinosarcoma 29 98.68 Very High Very High Very High
Colon Cancer 100 98.64 Very High Very High Very High
Carcinoma 68 98.42 Very High Very High Very High
Cancer 497 98.24 Very High Very High Very High
Ovarian Cancer 63 95.60 Very High Very High Very High
Injury 1 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the toxic effect exerted by 1 alpha,25(OH)2D3 and its analogues is accompanied by several of the biochemical features of apoptosis, such as DNA fragmentation and induction of the c-myc protooncogene.
Positive_regulation (induction) of c-myc associated with apoptosis
1) Confidence 0.67 Published 1996 Journal Cancer Lett. Section Abstract Doc Link 8620449 Disease Relevance 0.77 Pain Relevance 0.13
In AGS cells, a progressive increase in c-myc mRNA and protein levels was noted, while p53 and p21waf1/cip1 remained unchanged.
Positive_regulation (increase) of c-myc in AGS associated with alagille syndrome
2) Confidence 0.67 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.79 Pain Relevance 0
However, the magnitude and time course of acetaminophen and E2 induction of c-myc differed.
Positive_regulation (induction) of c-myc associated with paracetamol
3) Confidence 0.67 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11896290 Disease Relevance 0.34 Pain Relevance 0.83
i2, we therefore examined the time course of induction of c-Myc–I148E hCXCR2–C352I G?
Spec (examined) Positive_regulation (induction) of c-Myc
4) Confidence 0.67 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.27
The transcriptional activity of c-myc at the NOXA promoter can be favored by chromatin remodeling or modification proteins (including histone acetyl transferases, with acetylated histone H3 being a classical cofactor for myc).72 HDAC inhibition is also thought to interfere with the targeting of ubiquinated proteins via the aggresome for eventual autophagy/degradation by the lysozome, an alternate pathway to proteasome-mediated degradation.76
Positive_regulation (activity) of c-myc
5) Confidence 0.49 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.51 Pain Relevance 0
TCF-regulated genes, including c-Myc and NOS2, were also increased by expression of ?
Positive_regulation (increased) of c-Myc
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.11 Pain Relevance 0
Although the two pathways share transcriptional responsiveness of proliferative target genes, such as c-myc and cyclinD1, IL11 administration and excessive Stat3 activation also facilitates survival of epithelial cells with the capacity to repopulate the intestine after radiation damage [92] (Phesse T, Buchert M, Ernst M: Epistatic interaction between aberrant Wnt and Stat3 signaling during intestinal tumorigenesis, submitted).
Positive_regulation (responsiveness) of c-myc in intestine
7) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.37 Pain Relevance 0
We used these publicly available expression profiles and software to assess the activation probability of the c-Myc, H-Ras, c-Src, E2F3, and ?
Positive_regulation (activation) of c-Myc
8) Confidence 0.49 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.19 Pain Relevance 0
i2 expression were unaffected by the induction of c-Myc–I148E hCXCR2–C352I G?
Positive_regulation (induction) of c-Myc
9) Confidence 0.49 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.09 Pain Relevance 0.08
It can be concluded that wild-type p53 and/or up-regulation of c-myc is associated with indomethacin-mediated differential apoptosis in gastric epithelial cells.
Positive_regulation (up-regulation) of c-myc in epithelial cells associated with apoptosis
10) Confidence 0.49 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.78 Pain Relevance 0
Our data show that c-Myc is induced by APAP and that c-Myc-centered interactomes are the most significant networks of proteins associated with liver injury.
Positive_regulation (induced) of c-Myc in liver associated with injury
11) Confidence 0.49 Published 2007 Journal Toxicol. Sci. Section Abstract Doc Link 17562736 Disease Relevance 0.27 Pain Relevance 0.07
Increased transcriptional initiation of c-myc induced by the short-chain fatty acid, butyrate, consistent with elevated beta-catenin/TCF activity, was efficiently abrogated by a block to transcriptional elongation, resulting in decreased c-myc expression. 1alpha,25-Dihydroxyvitamin D(3) also induced transcriptional blockage.
Positive_regulation (induced) of c-myc
12) Confidence 0.49 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.40 Pain Relevance 0.08
Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc.
Positive_regulation (up-regulation) of c-myc in epithelial cells associated with apoptosis
13) Confidence 0.49 Published 1999 Journal Biochem. Pharmacol. Section Title Doc Link 10403534 Disease Relevance 0.91 Pain Relevance 0.20
Some of these miRNAs mediate key mRNA targets such as Ras, E2F5, c-myc, eIF5A, and PP2B.
Positive_regulation (mediate) of c-myc
14) Confidence 0.45 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.74 Pain Relevance 0
One of the genes located within 8q is C-MYC (8q24) found to be amplified in 18 of 23 uterine and ovarian carcinosarcomas through FISH and overexpression in 9 of 9 uterine carcinosarcomas through immunostaining.
Positive_regulation (amplified) of C-MYC in uterine associated with carcinosarcoma
15) Confidence 0.45 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.62 Pain Relevance 0
Although no evidence for gene rearrangements or amplification of the nuclear proto-oncogenes has been noted in thyroid carcinomas, in human MTC samples, both a high frequency of c-myc allelic losses [50] and elevated levels of c-myc and c-jun mRNA have been demonstrated [52].
Positive_regulation (elevated) of c-myc in thyroid associated with thyroid neoplasm and carcinoma
16) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.89 Pain Relevance 0
In contrast to this, c-Myc was found to be amplified in 23% (3/13) of BRCA1 and 67% (4/6) BRCA2 tumours.
Positive_regulation (amplified) of c-Myc associated with cancer
17) Confidence 0.45 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.16 Pain Relevance 0
A 5-30 min exposure to beta-endorphin resulted in an increase in the rate of mitogen-stimulated intracellular calcium release and an increase in c-myc mRNA levels relative to controls.
Positive_regulation (increase) of c-myc
18) Confidence 0.45 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 2139666 Disease Relevance 0 Pain Relevance 0.20
The inhibition of MYC upregulation in the coxP cells following treatment may thus be related to the observed APHS-mediated growth inhibition.
Positive_regulation (upregulation) of MYC
19) Confidence 0.20 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.23 Pain Relevance 0.03
However, concommitant c-MYC elevation actually has the consequence of reducing megakaryocytopoiesis, and decreasing polyploidization [62].
Positive_regulation (elevation) of c-MYC
20) Confidence 0.09 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.26 Pain Relevance 0

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