INT20422

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Context Info
Confidence 0.61
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 5.24
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
sciatic nerve 2
hypothalamus 1
neurons 1
synapses 1
dorsal horn 1
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 78 99.92 Very High Very High Very High
Dorsal horn 12 99.68 Very High Very High Very High
Hippocampus 14 99.16 Very High Very High Very High
qutenza 2 99.16 Very High Very High Very High
substance P 7 98.72 Very High Very High Very High
Peripheral nerve injury 7 98.60 Very High Very High Very High
Sciatic nerve 9 98.56 Very High Very High Very High
tetrodotoxin 1 98.56 Very High Very High Very High
anesthesia 3 98.52 Very High Very High Very High
fluoxetine 5 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 440 99.84 Very High Very High Very High
Contusions 13 99.36 Very High Very High Very High
Nervous System Injury 10 98.60 Very High Very High Very High
Injury 56 98.56 Very High Very High Very High
Urological Neuroanatomy 9 96.12 Very High Very High Very High
Syndrome 9 93.32 High High
Pain 14 92.92 High High
Spasticity 1 92.24 High High
Ataxia 2 91.48 High High
Autonomic Dysreflexia 1 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that levels of GAP-43 and neurogranin are regulated by factors known to modulate synaptic strength, thus providing a potential mechanism by which protein kinase C signaling pathways and their substrates might contribute to synaptic function and/or plasticity.
Regulation (regulated) of GAP-43 associated with kinase c
1) Confidence 0.61 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 18005072 Disease Relevance 0 Pain Relevance 0.23
These results suggest that venlafaxine and imipramine, but not fluoxetine, induce neuroplastic effects in the hippocampus through stimulation of BDNF mRNA expression, and that the effect on BDNF is not directly translated into regulation of synaptophysin and GAP-43 mRNA.
Regulation (regulation) of GAP-43 mRNA in hippocampus associated with hippocampus and fluoxetine
2) Confidence 0.58 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.53
In previous studies, we demonstrated changes in individual patterns of immunoreactivity for growth-associated protein-43, dopamine beta-hydroxylase and substance P that suggest growth and/or changes in expression of neurotransmitter enzymes and peptides in the cord caudal to a transection injury.
Regulation (immunoreactivity) of growth-associated protein-43 associated with neurotransmitter, dopamine, injury and substance p
3) Confidence 0.44 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336136 Disease Relevance 1.01 Pain Relevance 0.57
These observations might be explained by an up-regulation of growth-associated protein 43 (GAP-43) expression because improvements in neurological dysfunction were blocked by injection of MK-801 in the PBSC-treated group.
Regulation (regulation) of growth-associated protein 43 associated with anesthesia
4) Confidence 0.42 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19235891 Disease Relevance 0.33 Pain Relevance 0.19
These observations might be explained by an up-regulation of growth-associated protein 43 (GAP-43) expression because improvements in neurological dysfunction were blocked by injection of MK-801 in the PBSC-treated group.
Regulation (regulation) of GAP-43 associated with anesthesia
5) Confidence 0.42 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19235891 Disease Relevance 0.33 Pain Relevance 0.19
In investigating the mechanism of GAP-43 regulation, blockade of axon transport in the sciatic nerve with vinblastine (10(-5) M-10(-4) M) or capsaicin (1.5%) was found to produce a pattern of GAP-43 immunoreactivity in the dorsal horn identical to that found with crush, while electrical stimulation of the sciatic nerve had no effect.
Regulation (immunoreactivity) of GAP-43 in sciatic nerve associated with qutenza, dorsal horn and sciatic nerve
6) Confidence 0.27 Published 1990 Journal Neuroscience Section Abstract Doc Link 2139720 Disease Relevance 0.45 Pain Relevance 0.61
In investigating the mechanism of GAP-43 regulation, blockade of axon transport in the sciatic nerve with vinblastine (10(-5) M-10(-4) M) or capsaicin (1.5%) was found to produce a pattern of GAP-43 immunoreactivity in the dorsal horn identical to that found with crush, while electrical stimulation of the sciatic nerve had no effect.
Spec (investigating) Regulation (regulation) of GAP-43 in sciatic nerve associated with qutenza, dorsal horn and sciatic nerve
7) Confidence 0.27 Published 1990 Journal Neuroscience Section Abstract Doc Link 2139720 Disease Relevance 0.47 Pain Relevance 0.62
Our results indicate that peripheral nerve injury induces novel synapse formation of A fibers in lamina II but that up-regulated levels of GAP-43 are present mainly in other axon projections to the superficial dorsal horn.
Regulation (regulated) of GAP-43 in dorsal horn associated with nervous system injury, dorsal horn and peripheral nerve injury
8) Confidence 0.26 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9303528 Disease Relevance 0.30 Pain Relevance 0.48
Gap43 immunoreactivity was only apparent in a small percentage of the DTMR labeled neurons 1-week p.i.
Regulation (immunoreactivity) of Gap43 in neurons
9) Confidence 0.14 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.92 Pain Relevance 0
ERs may also play a role in neuropsychiatric disorders as ERalpha mRNA is decreased in the amygdala, frontal cortex, and hippocampus in major psychiatric illnesses.93,131,132 The human forebrain has discrete ERalpha mRNA expression,133 and synapses in the hippocampus depend on estrogen.134,135 Estrogen also regulates the growth-associated protein, GAP-43, in the rat hypothalamus, and GAP-43 is abnormal in schizophrenia.136–138
Regulation (regulates) of GAP-43 in hypothalamus associated with urological neuroanatomy, hippocampus, amygdala and schizophrenia
10) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.74 Pain Relevance 0.17
ERs may also play a role in neuropsychiatric disorders as ERalpha mRNA is decreased in the amygdala, frontal cortex, and hippocampus in major psychiatric illnesses.93,131,132 The human forebrain has discrete ERalpha mRNA expression,133 and synapses in the hippocampus depend on estrogen.134,135 Estrogen also regulates the growth-associated protein, GAP-43, in the rat hypothalamus, and GAP-43 is abnormal in schizophrenia.136–138
Regulation (abnormal) of GAP-43 in synapses associated with urological neuroanatomy, hippocampus, amygdala and schizophrenia
11) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.67 Pain Relevance 0.14

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