INT20423

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 6.63
Pain Relevance 6.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
neurons 4
neuronal 2
sensory neurons 2
nerve 2
Purkinje cells 2
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 29 100.00 Very High Very High Very High
Pain 39 99.48 Very High Very High Very High
nociceptor 2 99.48 Very High Very High Very High
Root ganglion neuron 2 99.40 Very High Very High Very High
ischemia 200 99.28 Very High Very High Very High
noradrenaline 3 98.76 Very High Very High Very High
Nerve growth factor 17 97.80 Very High Very High Very High
substance P 3 97.52 Very High Very High Very High
Eae 8 97.44 Very High Very High Very High
cerebral cortex 1 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 14 99.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 218 99.44 Very High Very High Very High
Cv Unclassified Under Development 184 99.28 Very High Very High Very High
Ganglion Cysts 15 99.20 Very High Very High Very High
Death 39 98.36 Very High Very High Very High
Injury 112 97.44 Very High Very High Very High
Disease 8 95.32 Very High Very High Very High
INFLAMMATION 102 95.28 Very High Very High Very High
Demyelinating Disease 4 93.40 High High
Repression 4 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Axotomy of primary sensory neurons or the interruption of axon transport in the periphery therefore acts to trigger GAP-43 production in the cell body.
Positive_regulation (trigger) of Gene_expression (production) of GAP-43 in primary sensory neurons
1) Confidence 0.70 Published 1990 Journal Neuroscience Section Abstract Doc Link 2139720 Disease Relevance 0.36 Pain Relevance 0.54
In situ hybridization histochemistry (ISH) revealed that at day 8 after the capsaicin treatment GAP-43 expression was significantly increased in small DRG cells as compared to control animals, and treatment with NGF in capsaicinized rats lead to an even more pronounced increase of GAP-43 expression in the small-sized cell population.
Positive_regulation (increased) of Gene_expression (expression) of GAP-43 associated with qutenza
2) Confidence 0.70 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10511462 Disease Relevance 0 Pain Relevance 0.63
Increased expression of GAP-43 in small sensory neurons after stimulation by NGF indicative of neuroregeneration in capsaicin-treated rats.
Positive_regulation (Increased) of Gene_expression (expression) of GAP-43 in sensory neurons associated with qutenza
3) Confidence 0.70 Published 1999 Journal Regul. Pept. Section Title Doc Link 10511462 Disease Relevance 0 Pain Relevance 0.56
In situ hybridization histochemistry (ISH) revealed that at day 8 after the capsaicin treatment GAP-43 expression was significantly increased in small DRG cells as compared to control animals, and treatment with NGF in capsaicinized rats lead to an even more pronounced increase of GAP-43 expression in the small-sized cell population.
Positive_regulation (increase) of Gene_expression (expression) of GAP-43 associated with qutenza
4) Confidence 0.70 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10511462 Disease Relevance 0 Pain Relevance 0.64
We found that GAP-43 expression increased 3-fold, peaking between 7 and 14 days after development of the CCI.
Positive_regulation (increased) of Gene_expression (expression) of GAP-43 associated with eae
5) Confidence 0.66 Published 1994 Journal Pain Section Abstract Doc Link 7526320 Disease Relevance 0.60 Pain Relevance 0.70
Extracorporeal shockwaves induce the expression of ATF3 and GAP-43 in rat dorsal root ganglion neurons.
Positive_regulation (induce) of Gene_expression (expression) of GAP-43 in dorsal root ganglion associated with ganglion cysts, nociceptor and root ganglion neuron
6) Confidence 0.47 Published 2006 Journal Auton Neurosci Section Title Doc Link 16716760 Disease Relevance 0.50 Pain Relevance 0.76
The expression of a marker protein for growth processes in cells of sympathetic or sensory ganglia, growth-associated protein-43, was significantly increased by the FK506 treatment.
Positive_regulation (increased) of Gene_expression (expression) of growth-associated protein-43 in ganglia
7) Confidence 0.38 Published 2002 Journal Pharmacology Section Abstract Doc Link 12169765 Disease Relevance 0 Pain Relevance 0.63
However, in transgenic mice where Gap43 is overexpressed in Purkinje cells, even though axonal sprouting occurs, axotomy leads to cell loss unless these neurons are protected by factors in embryonic grafts placed near the severed axons, as reviewed in [48].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Gap43 in Purkinje cells associated with targeted disruption
8) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 1.01 Pain Relevance 0.03
HFES of sympathetic neurons induced a frequency dependent NGF and NT-3 gene and protein up-regulation (relative NGF protein expression: 0Hz=1+/-0.0 vs. 5Hz=1.13+/-0.19 vs. 50Hz=1.77+/-0.08, all n=5, 0Hz/5Hz vs. 50Hz p<0.05), with a subsequent increase of growth associated protein 43 (GAP-43) expression and morphological SNS.
Positive_regulation (increase) of Gene_expression (expression) of associated protein 43 in neurons associated with nerve growth factor
9) Confidence 0.30 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.30 Pain Relevance 0.50
LPS resulted in increased expression of a number of regenerative associated genes (e.g., Gap-43, Scg10, and Chl1) in CST neurons, although this regenerative response did not contribute to sprouting or regeneration of CST axons damaged in the spinal cord at the time of LPS application [48].
Positive_regulation (increased) of Gene_expression (expression) of Gap-43 in neurons associated with spinal cord
10) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.89 Pain Relevance 0.48
As shown in figure 6, photothrombotic ischemia led to a significant and sustained increase in post-ischemic GAP-43 expression at 8, 15 and 30 d in P1 (Fig. 6A) and at 15 and 30 d in P2 (Fig. 6B) as compared to control values.
Positive_regulation (increase) of Gene_expression (expression) of GAP-43 associated with ischemia
11) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.25 Pain Relevance 0.13
Indeed, the expression of GAP-43, an intracellular growth protein playing a role in sprouting, neuronal pathfinding and branching [53] and the expression of synaptophysin, an integral membrane protein of synaptic vesicles, widely used as an immunohistological marker for the determination of synaptogenesis [54] were both significantly reduced in 3-AB treated animals as compared to vehicle treated animals.
Positive_regulation (reduced) of Gene_expression (expression) of GAP-43 in neuronal
12) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.56 Pain Relevance 0.20
Indeed, in a model of cervical axotomy, BDNF injection has been reported to stimulate GAP-43 expression and consequently axogenesis and repair [67].
Positive_regulation (stimulate) of Gene_expression (expression) of GAP-43
13) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.30 Pain Relevance 0.07
Concerning GAP-43 expression, 3-AB treatment induces a reduced expression already significant at 8 d and at one month post-ischemia whereas statistical differences were found for synaptophysin expression at longer time points (15 and 30 d of ischemia) between the two groups of animals.
Positive_regulation (induces) of Gene_expression (expression) of GAP-43 associated with ischemia
14) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.53 Pain Relevance 0.19
Additionally, the lack of increased expression of the axonal regeneration marker GAP-43 (Schreyer and Skene, 1991), as well as a lack of macrophages in the distal nerve, indicate that widespread axonal damage and regeneration, especially of larger diameter fibres, is not a significant consequence of this model.
Positive_regulation (increased) of Gene_expression (expression) of GAP-43 in nerve
15) Confidence 0.09 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.69 Pain Relevance 0.59
Perineural HIV-1 gp120 is associated with increased ATF3, caspase-3 but not GAP-43 or c-Jun expression in the DRG
Positive_regulation (increased) of Gene_expression (expression) of GAP-43 associated with acquired immune deficiency syndrome or hiv infection
16) Confidence 0.07 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.64 Pain Relevance 0.13

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