INT20424

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Context Info
Confidence 0.52
First Reported 1986
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
caudate putamen 1
vas deferens 1
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 13 100.00 Very High Very High Very High
tail-flick 1 76.64 Quite High
Neuropeptide 2 75.00 Quite High
antinociception 1 75.00 Quite High
Potency 1 75.00 Quite High
narcan 1 25.00 Low Low
Endogenous opioid 1 25.00 Low Low
Analgesic 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A good correlation exists between the high enzyme activity of neutral endopeptidase (EC 3.4.24.11) and the rapid degradation of des-enkephalin-gamma-endorphin and [cycloN alpha 6, C delata 11]beta-endorphin-[6-17] in caudate putamen.
Protein_catabolism (degradation) of des-enkephalin-gamma-endorphin in caudate putamen associated with enkephalin
1) Confidence 0.52 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2140132 Disease Relevance 0 Pain Relevance 0.31
The characteristics of the enkephalin-degradative enzymes in rat vas deferens were discussed in terms of their similarities to and differences from those in the other preparations.
Protein_catabolism (degradative) of enkephalin-degradative in vas deferens associated with enkephalin
2) Confidence 0.45 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3540390 Disease Relevance 0 Pain Relevance 0.53
Previous in vitro studies showed that the degradation of [Met(5)]enkephalin-Arg-Gly-Leu by cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors: amastatin, captopril and phosphoramidon.
Protein_catabolism (degradation) of enkephalin-Arg-Gly-Leu associated with enkephalin
3) Confidence 0.09 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12393059 Disease Relevance 0 Pain Relevance 0.43

General Comments

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