INT20425

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Context Info
Confidence 0.81
First Reported 1987
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 23
Total Number 26
Disease Relevance 5.18
Pain Relevance 9.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 5
central nervous system 3
plasma 2
heart 2
pituitary gland 2
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 50 100.00 Very High Very High Very High
Dynorphin 10 100.00 Very High Very High Very High
headache 7 100.00 Very High Very High Very High
Cluster headache 4 100.00 Very High Very High Very High
cva 40 99.64 Very High Very High Very High
Central nervous system 15 99.52 Very High Very High Very High
Inflammation 6 99.48 Very High Very High Very High
Neurotransmitter 19 98.76 Very High Very High Very High
Pyramidal cell 11 94.12 High High
Neuropeptide 31 93.32 High High
Disease Link Frequency Relevance Heat
Hyperplasia 100 100.00 Very High Very High Very High
Heart Rate Under Development 74 100.00 Very High Very High Very High
Pneumonia 44 100.00 Very High Very High Very High
Paroxysmal Hemicrania 4 100.00 Very High Very High Very High
Cluster Headache 4 100.00 Very High Very High Very High
Respiratory Disease 22 99.84 Very High Very High Very High
Pulmonary Embolism 40 99.64 Very High Very High Very High
INFLAMMATION 4 99.48 Very High Very High Very High
Asthma 20 99.24 Very High Very High Very High
Bronchitis 6 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using in situ hybridization with 35S-labeled oligonucleotide probes, we have mapped the localization of CPE mRNA in the rat brain.
Localization (localization) of CPE mRNA in brain
1) Confidence 0.81 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0 Pain Relevance 0.26
The widespread yet specific localization of CPE mRNA in the rat brain suggests it may be an excellent marker for peptide synthesizing cells in the CNS.
Localization (localization) of CPE mRNA in brain
2) Confidence 0.81 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0.09 Pain Relevance 0.41
In general, the localization of CPE mRNA in the rat brain corresponded to the distribution of enkephalin and other peptide neurotransmitter-synthesizing neurons, though CPE mRNA was also present in neurons that do not secrete known peptides and in reactive glia.
Localization (localization) of CPE mRNA in brain associated with neurotransmitter and enkephalin
3) Confidence 0.81 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0.10 Pain Relevance 0.45
Carboxypeptidase E (CPE): immunocytochemical localization in the rat central nervous system and pituitary gland.
Localization (localization) of Carboxypeptidase E in central nervous system associated with central nervous system
4) Confidence 0.80 Published 1990 Journal J. Neurosci. Section Title Doc Link 2332799 Disease Relevance 0 Pain Relevance 0.40
Review of the literature suggests that simultaneous occurrence of CH and CPH in a patient may be both over and under reported.
Localization (occurrence) of CPH associated with cluster headache and headache
5) Confidence 0.74 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19277837 Disease Relevance 0.99 Pain Relevance 0.99
Carboxypeptidase E (CPE): immunocytochemical localization in the rat central nervous system and pituitary gland.
Localization (localization) of CPE in central nervous system associated with central nervous system
6) Confidence 0.70 Published 1990 Journal J. Neurosci. Section Title Doc Link 2332799 Disease Relevance 0 Pain Relevance 0.40
In the present study we have localized CPE in the rat central nervous system using specific polyclonal antisera to the purified enzyme.
Localization (localized) of CPE in central nervous system associated with central nervous system
7) Confidence 0.61 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2332799 Disease Relevance 0 Pain Relevance 0.32
To directly examine the cellular effects of CPE on DAT, we analyzed subcellular localization of DAT and CPE in transfected HEK-293 cells using confocal immunofluorescence microscopy.
Spec (analyzed) Localization (localization) of CPE
8) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.14
DAT could be found both at the cell surface and within cell, whereas CPE located throughout the cytoplasm (Fig. 3A, B).
Localization (located) of CPE
9) Confidence 0.46 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.09
In virtually all cells coexpressing DAT and CPE, DAT was largely found at the plasma membrane and colocalized with CPE (Fig. 3C).
Localization (colocalized) of CPE in plasma
10) Confidence 0.46 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
However, cyclization of des-enkephalin-gamma-endorphin forming an amide bond between the alpha-NH2 of the N-terminal threonine and the gamma-COOH of glutamic acid did not improve peptide stability in any brain region tested.
Localization (cyclization) of des-enkephalin-gamma-endorphin in brain associated with enkephalin
11) Confidence 0.39 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2140132 Disease Relevance 0 Pain Relevance 0.32
The aim of the present study was to examine the presence of POMC, carboxypeptidase E, the prohormone convertases 1 (PC1), and 2 (PC2), PC2-binding protein 7B2, and the release of END from inflammatory cells in rats.
Localization (release) of carboxypeptidase E associated with inflammation
12) Confidence 0.39 Published 2004 Journal Endocrinology Section Abstract Doc Link 14630714 Disease Relevance 0.36 Pain Relevance 0.42
These cells were found to secrete two enzyme activities previously implicated in the processing of dynorphin, a monobasic cleaving 'dynorphin converting enzyme' and 'carboxypeptidase E', based on inhibitor sensitivities and pH optima.
Localization (secrete) of carboxypeptidase E associated with dynorphin
13) Confidence 0.39 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8375574 Disease Relevance 0 Pain Relevance 0.31
Carboxypeptidase E (CPE): immunocytochemical localization in the rat central nervous system and pituitary gland.
Localization (localization) of Carboxypeptidase E in pituitary gland associated with central nervous system
14) Confidence 0.27 Published 1990 Journal J. Neurosci. Section Title Doc Link 2332799 Disease Relevance 0 Pain Relevance 0.40
CPH was judged to be generally present/absent within the cervical spine as a whole, regardless of whether hyperplastic pillars were detected at one or more levels from C3 to C6), the etiology and clinical relevance of CPH remain unknown.
Localization (relevance) of CPH in spine associated with hyperplasia
15) Confidence 0.27 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1592100 Disease Relevance 1.24 Pain Relevance 0.07
Carboxypeptidase E (CPE): immunocytochemical localization in the rat central nervous system and pituitary gland.
Localization (localization) of CPE in pituitary gland associated with central nervous system
16) Confidence 0.24 Published 1990 Journal J. Neurosci. Section Title Doc Link 2332799 Disease Relevance 0 Pain Relevance 0.40
We have localized enkephalin convertase in the brain and other tissues autoradiographically by labeling studies with [3H]guanidinoethylmercaptosuccinic acid ([3H]GEMSA).
Localization (localized) of enkephalin convertase in brain associated with enkephalin
17) Confidence 0.21 Published 1988 Journal Biochimie Section Abstract Doc Link 3135843 Disease Relevance 0 Pain Relevance 0.48
In virtually all cells coexpressing DAT and CPE, DAT was largely found at the plasma membrane and colocalized with CPE (Fig. 3C).
Localization (colocalized) of CPE in plasma
18) Confidence 0.20 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.03
Enkephalin convertase: characterization and localization using [3H]guanidinoethylmercaptosuccinic acid.
Localization (localization) of Enkephalin convertase associated with enkephalin
19) Confidence 0.20 Published 1988 Journal Biochimie Section Title Doc Link 3135843 Disease Relevance 0 Pain Relevance 0.50
Enkephalin convertase in the gastrointestinal tract an associated organs characterized and localized with [3H]guanidinoethylmercaptosuccinic acid.
Localization (localized) of Enkephalin convertase in associated organs associated with enkephalin
20) Confidence 0.18 Published 1987 Journal Endocrinology Section Title Doc Link 3109877 Disease Relevance 0 Pain Relevance 0.49

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