INT204254

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 6.78
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
Anatomy Link Frequency
precursor cells 1
smooth muscle 1
epithelium 1
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 59 96.44 Very High Very High Very High
abdominal pain 7 81.32 Quite High
Inflammation 80 50.04 Quite High
Crohn's disease 8 5.00 Very Low Very Low Very Low
positron emission tomography 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Adalimumab 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Histiocytic Sarcoma 33 99.80 Very High Very High Very High
Cancer 238 99.48 Very High Very High Very High
Sarcoma 16 98.84 Very High Very High Very High
Melanoma 1 98.32 Very High Very High Very High
Carcinoma 3 98.10 Very High Very High Very High
Disease 116 96.88 Very High Very High Very High
Gastrointestinal Stromal Tumor 174 96.60 Very High Very High Very High
Testicular Cancer 147 96.08 Very High Very High Very High
Malignant Neoplastic Disease 15 94.00 High High
Diffuse Large B-cell Lymphoma 1 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most important immunohistochemical markers of GISTs are expression of KIT (CD117), which is found in over 90 percent of GISTs, and CD34 which occurs in over 80 percent [11].
Localization (found) of KIT
1) Confidence 0.73 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2965163 Disease Relevance 0.86 Pain Relevance 0.08
The most important immunohistochemical markers of GISTs are expression of KIT (CD117), which is found in over 90 percent of GISTs, and CD34 which occurs in over 80 percent [11].
Localization (found) of CD117
2) Confidence 0.68 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2965163 Disease Relevance 0.86 Pain Relevance 0.08
When both tumours from bilateral cases could be assessed, an identical KIT mutation was observed.
Localization (mutation) of KIT associated with cancer
3) Confidence 0.64 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 2.10 Pain Relevance 0
Five patients had sufficient tumor for genotyping, and were KIT or PDGFRA wild-type.
Localization (wild-type) of KIT associated with cancer
4) Confidence 0.62 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.04 Pain Relevance 0
Additionally, aberrant c-kit expression was localized within the epithelium that had grown over the amniotic membrane.
Localization (localized) of c-kit in epithelium
5) Confidence 0.51 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.12 Pain Relevance 0.04
In fact, during pancreatic development, differentiated cells derive from the PDX-1+ ductal precursor cells: consequently, colocalization of c-kit/PDX-1 could coincide with endocrine ?
Localization (colocalization) of c-kit in precursor cells
6) Confidence 0.51 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Unlike some authors [29] and according to others [30], we have observed, in our cell monolayers, c-kit and insulin colocalization by factor 3-4 at 21 days of culture.
Localization (colocalization) of c-kit
7) Confidence 0.47 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Other tumors, such as carcinomas, melanomas, and soft tissue sarcomas, primary or metastatic, can be confused with HS and were excluded in our case by the lack of immunoreactivity for pancytokeratin, CAM 5.2, CK 903, TTF1, HMB45, MART-1/Melan A, CD99, CD117, smooth muscle actin, desmin, and myogenin.
Localization (excluded) of CD117 in smooth muscle associated with sarcoma, melanoma, cancer, histiocytic sarcoma and carcinoma
8) Confidence 0.28 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.79 Pain Relevance 0.03
The secretion of IL-17 by PBT and LPT was determined using an IL-17A specific ELISA (eBioscience).
Spec (determined) Localization (secretion) of PBT
9) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.22
Furthermore, when PBT were activated by anti-CD3 and LPT by anti-CD2 and cultured for 48 h IL-17 secretion, determined by an IL-17 specific ELISA, dropped by 20±2.5% and 29±3%, respectively (Fig. 4B).
Localization (cultured) of PBT
10) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox