INT204286

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.85
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bid) mitochondrion (Bid) cytoplasm (Bid)
Anatomy Link Frequency
cleavage 2
Bid (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 4 97.22 Very High Very High Very High
Glutamate receptor 12 67.84 Quite High
nMDA receptor 2 66.48 Quite High
agonist 4 66.32 Quite High
Glutamate 2 59.12 Quite High
tetrodotoxin 4 47.28 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 64 99.98 Very High Very High Very High
Death 86 99.62 Very High Very High Very High
Injury 10 67.96 Quite High
Hypoxia 4 67.04 Quite High
Neurodegenerative Disease 2 60.60 Quite High
Cancer 2 55.52 Quite High
Necrosis 2 55.04 Quite High
Infection 6 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a fluorescence resonance energy transfer single-cell imaging approach of Bid cleavage and translocation during apoptosis, we have recently demonstrated that caspase-independent excitotoxic apoptosis induces a translocation of full length Bid (FL-Bid) from the cytosol to mitochondria [28].
Positive_regulation (induces) of Localization (translocation) of Bid in cleavage associated with apoptosis and imagery
1) Confidence 0.40 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.22 Pain Relevance 0.15
Changes in the intracellular phospholipid environment during excitotoxic cell death signals may hence induce the translocation of FL-Bid to mitochondria and may initiate the release of pro-apoptotic factors from mitochondria.


Spec (may) Positive_regulation (induce) of Localization (translocation) of Bid associated with apoptosis and death
2) Confidence 0.40 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.63 Pain Relevance 0.03

General Comments

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