INT204290

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 5.19
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bak1) cytosol (Bak1) mitochondrion (Bak1)
aging (Bak1) endoplasmic reticulum (Bak1) intracellular (Bak1)
Anatomy Link Frequency
apoptotic cells 2
retina 1
pore 1
Bak1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 224 90.16 High High
Glutamate 2 74.16 Quite High
Glutamate receptor 12 65.72 Quite High
anesthesia 21 60.88 Quite High
Central nervous system 14 28.84 Quite Low
isoflurane 14 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 288 99.84 Very High Very High Very High
Death 135 96.92 Very High Very High Very High
Stress 23 93.44 High High
Coronary Artery Disease 7 90.16 High High
Retina Disease 119 89.04 High High
Cv Unclassified Under Development 77 83.68 Quite High
Hypoxia 11 79.20 Quite High
Neurodegenerative Disease 2 71.92 Quite High
Ocular Hypertension 56 68.52 Quite High
Injury 31 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bak was upregulated at the mRNA level (2.462±0.103) but this was not confirmed at the protein level (0.717±0.387).
Positive_regulation (upregulated) of Bak
1) Confidence 0.22 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.33 Pain Relevance 0.06
Analyses 24 h post I/R revealed that Bax and Bcl-xL were downregulated (0.841±0.033, p<0.05, and 0.604±0.025, p<0.01, respectively) while Bak was upregulated (1.478±0.052, p<0.001; Figure 3A-B,D).
Positive_regulation (upregulated) of Bak
2) Confidence 0.22 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0
Therefore, it would be interesting to study Bnip3-induced activation of Bax and Bak and to analyze whether Bnip-3 could also be associated with the increase in apoptosis observed after I/R in the retina.
Positive_regulation (activation) of Bak in retina associated with apoptosis
3) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.77 Pain Relevance 0.07
At the protein level, Bcl-2 and Bcl-xL increased 3 h after I/R (1.446±0.163, and 1.697±0.294, respectively) while Bax and Bak levels increased slightly but not significantly (1.171±0.136, 1.769±0.531; Figure 2A-D).
Neg (not) Positive_regulation (increased) of Bak
4) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.10 Pain Relevance 0.09
The strong upregulation seen for Bak at the mRNA level was not present at the protein level (1.270±0.177).
Positive_regulation (upregulation) of Bak
5) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.09 Pain Relevance 0
Bax and Bak activation, opening of the mitochondrial permeability transition pore (mPTP), and cell death have been reported to be mediated through Bcl-2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), a BH3-only protein localized primarily in mitochondria [32-34], although this is still controversial [35].
Positive_regulation (activation) of Bak in pore associated with death
6) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.87 Pain Relevance 0.08
At the late phase of recovery, Bax and Bcl-xL mRNAs were downregulated while Bak was increased.
Positive_regulation (increased) of Bak
7) Confidence 0.13 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2765238 Disease Relevance 0.82 Pain Relevance 0.22
In non-apoptotic cells, activation of Bax or Bak is inhibited by anti-apoptotic Bcl-2 family members such as Bcl-2 and Bcl-xL.
Positive_regulation (activation) of Bak in apoptotic cells associated with apoptosis
8) Confidence 0.08 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.07 Pain Relevance 0.09
In apoptotic cells, the transcriptional induction or post-translational activation of Bcl-2-homolgy domain-3 (BH3)-only proteins overcomes this inhibition and triggers the activation of Bax and Bak and the release of cyt-C [15,16].
Positive_regulation (activation) of Bak in apoptotic cells associated with apoptosis
9) Confidence 0.05 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.13 Pain Relevance 0.06

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