INT204291

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.31
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Apaf1) aging (Apaf1) Golgi apparatus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1) cytosol (Apaf1)
Anatomy Link Frequency
neuronal 1
Apaf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 6 58.00 Quite High
cytokine 4 41.40 Quite Low
Kinase C 21 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 115 100.00 Very High Very High Very High
Death 58 98.88 Very High Very High Very High
Cancer 2 96.84 Very High Very High Very High
Necrosis 6 96.60 Very High Very High Very High
Infection 31 74.12 Quite High
Stress 20 64.32 Quite High
Hypertrophy 3 64.20 Quite High
Cv General 4 Under Development 1 51.64 Quite High
Injury 19 50.64 Quite High
Rhinitis 12 47.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm As-induced mitochondria-dependent apoptosis, we determined the mitochondrial membrane potential, intracellular ATP level as well as expressions of Bcl-2 family and BH-3 only proteins, cytochrome c, caspase 3, caspase 9, Apaf1 and PARP in arsenic-induced hepatic pathophysiology and observed that As significantly up-regulated pro-apoptotic (Bad, Bax, Bim) and down-regulated anti-apoptotic (Bcl-2, Bcl-xL) proteins, reduced mitochondrial membrane potential and intracellular ATP level, increased cytochrome c release and protein level of Apaf-1 in the cytosol.
Gene_expression (expressions) of Apaf1 associated with apoptosis
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.87 Pain Relevance 0
There is also evidence that levels of Apaf-1 decrease during neuronal maturation, inhibiting apoptosome formation after mitochondrial outer membrane permeabilization (MOMP) [37].
Gene_expression (levels) of Apaf-1 in neuronal
2) Confidence 0.28 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.97 Pain Relevance 0.03
The up-regulated expressions of mitochondrial pathway mediated apoptosis factors (Bcl-2 associated protein X: BAX, Apoptotic protease activating factor 1: Apaf-1 and caspase 9) and death receptor pathway mediated apoptosis factors (tumor necrosis factor-alpha: TNF-?
Gene_expression (expressions) of Apoptotic protease activating factor 1 associated with necrosis, cancer, apoptosis and death
3) Confidence 0.03 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 1.47 Pain Relevance 0

General Comments

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