INT204293

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.07
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bid) mitochondrion (Bid) cytoplasm (Bid)
Anatomy Link Frequency
cleavage 3
neurons 2
plasma 1
Bid (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 16 99.74 Very High Very High Very High
cytokine 16 95.72 Very High Very High Very High
tetrodotoxin 16 82.28 Quite High
Glutamate receptor 48 79.76 Quite High
agonist 16 69.84 Quite High
Glutamate 8 64.16 Quite High
nMDA receptor 8 52.96 Quite High
Hippocampus 22 48.28 Quite Low
Inflammation 17 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 348 99.04 Very High Very High Very High
Apoptosis 276 98.96 Very High Very High Very High
Infection 84 95.44 Very High Very High Very High
Injury 43 93.44 High High
Cv General 4 Under Development 8 92.40 High High
Hypoxia 16 91.60 High High
Stress 9 86.88 High High
Disease 33 73.84 Quite High
Neurodegenerative Disease 18 65.64 Quite High
Necrosis 9 33.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cells will subsequently undergo plasma membrane leakage, a process that may limit the ability to detect Bid cleavage during the late stages of apoptosis.
Protein_catabolism (cleavage) of Bid in plasma associated with apoptosis
1) Confidence 0.65 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.70 Pain Relevance 0.03
However, we cannot exclude the possibility that Bid may be cleaved during the later stages of apoptosis, downstream of MOMP or an intracellular ion homeostasis breakdown [28,41,42].
Protein_catabolism (cleaved) of Bid associated with apoptosis
2) Confidence 0.65 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.75 Pain Relevance 0
It is likely that these events involve the caspase-8-mediated cleavage of the BH3-only protein Bid.
Protein_catabolism (cleavage) of Bid in cleavage
3) Confidence 0.56 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.04 Pain Relevance 0.09
Tetracycline (tet)-on inducible adenovirus vectors expressing wild-type FL-Bid or the D59A mutant of FL-Bid that can not be cleaved by caspase-8 were generated as described previously [32].
Neg (not) Protein_catabolism (cleaved) of Bid
4) Confidence 0.56 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.43 Pain Relevance 0.08
Using a single-cell imaging approach of Bid cleavage and translocation during apoptosis, we have recently demonstrated that, in contrast to death receptor-induced apoptosis, caspase-independent excitotoxic apoptosis involves a translocation of full length Bid (FL-Bid) from the cytosol to mitochondria.
Protein_catabolism (cleavage) of Bid in cleavage associated with apoptosis, imagery and death
5) Confidence 0.56 Published 2007 Journal BMC Cell Biol Section Abstract Doc Link PMC1808451 Disease Relevance 0.95 Pain Relevance 0.12
Using a fluorescence resonance energy transfer single-cell imaging approach of Bid cleavage and translocation during apoptosis, we have recently demonstrated that caspase-independent excitotoxic apoptosis induces a translocation of full length Bid (FL-Bid) from the cytosol to mitochondria [28].
Protein_catabolism (cleavage) of Bid in cleavage associated with apoptosis and imagery
6) Confidence 0.56 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.14 Pain Relevance 0.14
Mild overexpression of FL-Bid or a Bid mutant that can not be cleaved by caspase-8 potently induces cell death in cultured rat hippocampal neurons
Neg (not) Protein_catabolism (cleaved) of Bid in neurons associated with death
7) Confidence 0.56 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.34 Pain Relevance 0
We subsequently addressed the question, whether FL-Bid was sufficient to induce cell death in the hippocampal neuron cultures, and whether this cell death can occur in the absence of caspase-8-mediated Bid cleavage.
Protein_catabolism (cleavage) of Bid in neuron associated with death
8) Confidence 0.56 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.41 Pain Relevance 0
The up-regulation of the wnt ligand wnt5a and the calcium binding protein p22 (CHP) indicates an activation of the non-canonical Wnt/Ca2+ branch.
Protein_catabolism (protein) of p22
9) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.32 Pain Relevance 0

General Comments

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