INT204328

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.80
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 91.60 High High
bDMF 42 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 98.96 Very High Very High Very High
Disease 253 85.52 High High
Cardiovascular Disease 66 69.52 Quite High
Diabetes Mellitus 31 60.64 Quite High
Apoptosis 1 34.68 Quite Low
Disorder Of Lipid Metabolism 2 28.32 Quite Low
Obesity 11 5.40 Low Low
Weight Loss 2 5.04 Very Low Very Low Very Low
Aging 30 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rodents, knockout of the eNOS gene abolishes the caloric restriction-induced expression of PPARGC1A and TFAM mRNA and mitochondrial protein content [7].
Positive_regulation (induced) of Transcription (expression) of TFAM associated with targeted disruption
1) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.10 Pain Relevance 0
The hub genes included those encoding general transcription factor iiic, polypeptide 1, alpha 220 kda (GTF3C1), which is involved in RNA polymerase III-mediated transcription, microtubule-associated protein 4 (MAP4), which promotes microtubule stability and affects cell growth [28], and proprotein convertase subtilisin/kexin type 2 (PC2), which is responsible for the processing of neuropeptide precursors.
Positive_regulation (mediated) of Transcription (transcription) of transcription factor associated with neuropeptide
2) Confidence 0.08 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.85 Pain Relevance 0.05
The hub genes included those encoding general transcription factor iiic, polypeptide 1, alpha 220 kda (GTF3C1), which is involved in RNA polymerase III-mediated transcription, microtubule-associated protein 4 (MAP4), which promotes microtubule stability and affects cell growth [28], and proprotein convertase subtilisin/kexin type 2 (PC2), which is responsible for the processing of neuropeptide precursors.
Positive_regulation (involved) of Transcription (transcription) of transcription factor associated with neuropeptide
3) Confidence 0.08 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.85 Pain Relevance 0.05

General Comments

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