INT204328

Context Info Confidence 0.46 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.80 Pain Relevance 0.09

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)

TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropeptide 2 91.60 bDMF 42 5.00 Migraine 2 5.00 long-term potentiation 2 5.00 depression 2 5.00 Inflammatory response 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 1 98.96 Disease 253 85.52 Cardiovascular Disease 66 69.52 Diabetes Mellitus 31 60.64 Apoptosis 1 34.68 Disorder Of Lipid Metabolism 2 28.32 Obesity 11 5.40 Weight Loss 2 5.04 Aging 30 5.00 Neurodegenerative Disease 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In rodents, knockout of the eNOS gene abolishes the caloric restriction-induced expression of PPARGC1A and TFAM mRNA and mitochondrial protein content [7].

Positive_regulation (induced) of Transcription (expression) of TFAM associated with targeted disruption

1) Confidence 0.46 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.10 Pain Relevance 0

The hub genes included those encoding general transcription factor iiic, polypeptide 1, alpha 220 kda (GTF3C1), which is involved in RNA polymerase III-mediated transcription, microtubule-associated protein 4 (MAP4), which promotes microtubule stability and affects cell growth [28], and proprotein convertase subtilisin/kexin type 2 (PC2), which is responsible for the processing of neuropeptide precursors.

Positive_regulation (mediated) of Transcription (transcription) of transcription factor associated with neuropeptide

2) Confidence 0.08 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.85 Pain Relevance 0.05

The hub genes included those encoding general transcription factor iiic, polypeptide 1, alpha 220 kda (GTF3C1), which is involved in RNA polymerase III-mediated transcription, microtubule-associated protein 4 (MAP4), which promotes microtubule stability and affects cell growth [28], and proprotein convertase subtilisin/kexin type 2 (PC2), which is responsible for the processing of neuropeptide precursors.

Positive_regulation (involved) of Transcription (transcription) of transcription factor associated with neuropeptide

3) Confidence 0.08 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.85 Pain Relevance 0.05

General Comments

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