INT204330

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Context Info
Confidence 0.84
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.75
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
skeletal muscle 1
band 1
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 12 75.08 Quite High
palliative 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 117 99.48 Very High Very High Very High
Diabetes Mellitus 121 99.40 Very High Very High Very High
Motor Neuron Diseases 140 99.24 Very High Very High Very High
Death 26 98.76 Very High Very High Very High
Diabetes Complications 2 98.20 Very High Very High Very High
Paralysis 4 69.44 Quite High
Toxicity 30 69.12 Quite High
Neurodegenerative Disease 22 67.88 Quite High
Body Weight 1 54.20 Quite High
Aging 12 46.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association of enzyme activity and polymorphisms in SOD1 and SOD2 with diabetes control and vascular complications of diabetes mellitus
Protein_catabolism (polymorphisms) of SOD1 associated with diabetes complications and diabetes mellitus
1) Confidence 0.84 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.83 Pain Relevance 0
Relationship between the SOD2 Ala16Val (C/T) polymorphism and SOD activity in healthy subjects and patients with DM
Protein_catabolism (polymorphism) of SOD associated with diabetes mellitus
2) Confidence 0.84 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.53 Pain Relevance 0
Correlation between SOD1 variant stability and patient disease duration, however, required that the authors omit stability data of 4 of the 15 variants from their regression analysis (on the basis that these variants change the net charge of SOD1).
Protein_catabolism (stability) of SOD1 associated with disease
3) Confidence 0.66 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.44 Pain Relevance 0
Previous studies revealed a correlation [15] and conversely a lack of correlation [86] between SOD1 variant stability and patient disease duration.
Protein_catabolism (stability) of SOD1 associated with disease
4) Confidence 0.66 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.44 Pain Relevance 0
Biochemists discovered that different mutations result in remarkably different physical properties, for example, stability of Cu/Zn-superoxide dismutase.
Protein_catabolism (stability) of Cu/Zn-superoxide dismutase
5) Confidence 0.64 Published 2008 Journal PLoS Biology Section Abstract Doc Link PMC2486295 Disease Relevance 1.22 Pain Relevance 0.06
We also demonstrate that loss of Cu/Zn-superoxide dismutase stability relates to faster ALS patient death.
Protein_catabolism (stability) of Cu/Zn-superoxide dismutase associated with death and motor neuron diseases
6) Confidence 0.64 Published 2008 Journal PLoS Biology Section Abstract Doc Link PMC2486295 Disease Relevance 1.23 Pain Relevance 0.03
Lane loaded with DNase I digested pSOD showed no band, indicating the complete degradation of the DNA, while plasmid treated with vitreous humor showed a major degradation band, indicating the instability of the DNA in the vitreous humor.
Protein_catabolism (degradation) of pSOD in band
7) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Nuclease and vitreous liquid stability of pSOD in human serum albumin nanoparticles
Protein_catabolism (stability) of pSOD
8) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
In addition, the activity of superoxide dismutase (SOD), a free radical scavenging enzyme that catalyzes the breakdown of ROS to hydrogen peroxide and molecular oxygen, tended to decrease in the skeletal muscle of the CR group (?
Protein_catabolism (breakdown) of SOD in skeletal muscle
9) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.05 Pain Relevance 0

General Comments

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