INT204331

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1)
nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)
SIRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 83.92 Quite High
Chronic Disease 4 69.84 Quite High
Weight Loss 4 65.44 Quite High
Overweight 12 63.20 Quite High
Obesity 22 54.64 Quite High
Stress 20 20.04 Low Low
Aging 16 18.68 Low Low
Targeted Disruption 2 8.08 Low Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Helminth Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SIRT1 is known to bind, deacetylate, and activate PPARGC1A, thus promoting mitochondrial biogenesis [11].
SIRT1 Binding (bind) of
1) Confidence 0.47 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.19 Pain Relevance 0
The mammalian ortholog of Sir2, known as sirtuin 1 (SIRT1), deacetylates and activates PPARGC1A [11,14], suggesting a direct link between SIRT1 and mitochondrial bioenergetics.
SIRT1 Binding (link) of
2) Confidence 0.37 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.20 Pain Relevance 0

General Comments

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