INT204333

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PPARGC1A) mRNA processing (PPARGC1A) RNA binding (PPARGC1A)
mitochondrion organization (PPARGC1A) nucleus (PPARGC1A) protein complex assembly (PPARGC1A)
PPARGC1A (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 33 76.68 Quite High
Overweight 18 76.00 Quite High
Apoptosis 3 67.60 Quite High
Stress 30 64.24 Quite High
Appetite Loss 3 59.24 Quite High
Targeted Disruption 3 40.64 Quite Low
Weight Loss 6 37.96 Quite Low
Aging 24 25.00 Low Low
Chronic Disease 6 25.00 Low Low
Heart Disease 3 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of this concept, SIRT1 mRNA was increased in the CR and CREX groups in proportion to the increase in PPARGC1A mRNA, consistent with the potential role of SIRT1 as a direct regulator of PPARGC1A activity [11,14].
Regulation (regulator) of PPARGC1A
1) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0
The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS.
Regulation (regulation) of PPARGC1A
2) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.06 Pain Relevance 0
Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).
Regulation (involved) of PPARGC1A
3) Confidence 0.19 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0

General Comments

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