INT204333

Context Info Confidence 0.26 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.34 Pain Relevance 0

cytosol (PPARGC1A) mRNA processing (PPARGC1A) RNA binding (PPARGC1A) mitochondrion organization (PPARGC1A) nucleus (PPARGC1A) protein complex assembly (PPARGC1A)

PPARGC1A (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 3 5.00

Disease Link Frequency Relevance Heat Obesity 33 76.68 Overweight 18 76.00 Apoptosis 3 67.60 Stress 30 64.24 Appetite Loss 3 59.24 Targeted Disruption 3 40.64 Weight Loss 6 37.96 Aging 24 25.00 Chronic Disease 6 25.00 Heart Disease 3 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In support of this concept, SIRT1 mRNA was increased in the CR and CREX groups in proportion to the increase in PPARGC1A mRNA, consistent with the potential role of SIRT1 as a direct regulator of PPARGC1A activity [11,14].

Regulation (regulator) of PPARGC1A

1) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0

The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS.

Regulation (regulation) of PPARGC1A

2) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.06 Pain Relevance 0

Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).

Regulation (involved) of PPARGC1A

3) Confidence 0.19 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.21 Pain Relevance 0

General Comments

This test has worked.