INT204333
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In support of this concept, SIRT1 mRNA was increased in the CR and CREX groups in proportion to the increase in PPARGC1A mRNA, consistent with the potential role of SIRT1 as a direct regulator of PPARGC1A activity [11,14]. | |||||||||||||||
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The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS. | |||||||||||||||
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Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05). | |||||||||||||||
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General Comments
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