INT204337

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PPARGC1A) mRNA processing (PPARGC1A) RNA binding (PPARGC1A)
mitochondrion organization (PPARGC1A) nucleus (PPARGC1A) protein complex assembly (PPARGC1A)
Anatomy Link Frequency
skeletal muscle 2
PPARGC1A (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Disease 6 81.68 Quite High
Weight Loss 6 77.28 Quite High
Overweight 18 75.04 Quite High
Stress 30 70.84 Quite High
Obesity 33 53.76 Quite High
Aging 24 5.00 Very Low Very Low Very Low
Heart Disease 3 5.00 Very Low Very Low Very Low
Helminth Infection 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, there no data in human skeletal muscle on how caloric restriction may affect the expression of PPARGC1A and SIRT1, as well as mitochondrial number and function.
Spec (may) Regulation (affect) of Gene_expression (expression) of PPARGC1A in skeletal muscle
1) Confidence 0.44 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.29 Pain Relevance 0
The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS.
Regulation (change) of Gene_expression (expression) of PPARGC1A
2) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0
These data indicate that adiponectin signaling may be involved in the regulation of SIRT1-PPARGC1A protein expression.
Regulation (regulation) of Gene_expression (expression) of PPARGC1A
3) Confidence 0.26 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.12 Pain Relevance 0

General Comments

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